Locus Biosciences is seeking a highly motivated and entrepreneurial applicant to join our company in a full-time, entry-level position that will rotate between our Chemistry, Manufacturing and Controls (CMC) and Research & Development (R&D) departments in the first year. This position is well suited for those looking for an entry-level position that is excited to learn all aspects of biotechnology drug development from early-stage research through drug product manufacturing. Candidates will be expected to accomplish defined work, as well as assist in approaching and solving complex scientific problems. Candidates should have demonstrated laboratory or manufacturing experience, with solid communication, technical aptitude, and problem-solving skills. Experience working in regulated, pharmaceutical / biotechnology R&D (GDP, GLP) and / or manufacturing environments (cGMP) is strongly preferred, but not required.
Why Locus?
- Change the future of medicine and address a serious and unmet patient need by developing completely novel therapeutic modalities.
- Fast-track your career by tackling large & meaningful projects and learning a breadth of techniques and skillsets in the wet lab and manufacturing suites
- Work with a team of exceptionally talented and hardworking individuals while striving to achieve a common mission
- Partner with the most highly respected pharmaceutical companies in the world
- Bonus pool eligibility
- Health, dental, vision, life insurance, 401(k), and PTO
- Free access to fitness center and classes
Responsibilities will include :
Designing and / or executing formulation development activitiesDesigning and / or executing bench-scale process development activities, including set-up and operation of development-scale bioreactors, filter trains, tangential flow filtration (TFF) equipment, and chromatography equipmentDevelopment of analytical strategies to inform formulation and process development activitiesPerforming molecular biology and microbiology laboratory assaysMolecular biology and synthetic biology- Cloning, NGS library preparation, characterization of novel genetic engineering tools, and generation and analysis of novel engineered phage clonesMicrobiology - Culturing both aerobic and obligate anaerobic organisms. Utilizing a range of bacterial strains to produce and characterize activity of phageIndependent management, planning, and execution of multiple projects, including reviewing, interpreting, and recording results.Supporting tech transfer of new products and processes to ensure smooth transition from R&D to process development to GMP manufacturingForming strong relationships with all stakeholders, including technicians, associates, project and program managers, and scientists to enable successful tech transferSupporting Scientists in all aspects of pharmaceutical developmentAssisting in the preparation of batch records, protocols, SOPs, deviations, technical reports, presentations, and other CMC documents to support drug development, including INDs, BLAs, and other applicationsGaining aseptic gowning and fill qualificationPerforming material handling and stagingPracticing real-time documentation (such as batch records) during production run and maintain accurate records / logs according to GDPSupporting Qualification and Validation activitiesIdentifying, communicating, and troubleshooting process issuesSupporting team effort in the effective and timely completion of root cause investigations and CAPASupporting a high-performance teamwork environmentEducation :
Technical certificate or degree (e.g. BTEC Biomanufacturing), or graduation from an accredited college / university with a Bachelor's to a Master's degree in Biology, Chemistry, Biochemistry, Chemical Engineering, Biophysics, Pharmaceutical Technology or related field, with some lab experience (required)Experience and Expertise :
Familiarity with general laboratory techniques such as pipetting, serial dilutions, aseptic technique and proper decontamination proceduresExperience in research, pharmaceutical, biotechnology, and / or sterile production environmentExperience executing SOPs and documenting workStrong mechanical aptitudeExcellent oral and written communication skillsTechnical writing abilityThrives in a fast-paced, entrepreneurial and collaborative environment. Openly shares knowledge / information needed to accomplish a task or solve a problemPreferred Qualifications :
At least two years' experience between academic or industry researchExperience in biologics (upstream, downstream, aseptic fill / finish) with working knowledge of FDA regulations and GMP systemsExperience with DNA sequence analysis, including homology searching, sequence assembly and primer designAbility to assist in the design of experiments and interpretation of resultsMotivation to learn new processes that contribute to the company's overall desire to get products into the clinicTechnical proficiency with designing and executing standard molecular biology experiments (PCR, transformation, Gibson cloning)Experience with microbiology skills like growth curves, anaerobic microbiology, streaking and banking strainsThe level of the position will be based on the successful candidate's qualifications.About Locus Biosciences
Locus Biosciences is a clinical-stage biotechnology company developing precision antibacterial products to address critical unmet medical needs in treating bacterial infections and microbiome indications. The Locus platform engineers bacterial viruses called bacteriophages to specifically kill target pathogens while leaving non-target bacteria (i.e., the rest of the patient's microbiome) unharmed and to deliver biotherapeutic payloads to the body sites where they are needed. Locus's lead program is an engineered bacteriophage product targeting Escherichia coli bacteria in the urinary tract, currently being tested in an active Phase 2 / 3 clinical trial. Locus has collaborations with BARDA and CARB-X to develop engineered bacteriophage products targeting E. coli infections and Klebsiella pneumoniae infections, respectively. For more information about Locus visit https : / / www.locus-bio.com /
SHIFT : Full-Time Days, with occasional evening and weekend work
Job Type : Full-time, onsite
Job Location : Research Triangle Park, North Carolina
Direct applicants only. No agencies please.
