What are the responsibilities and job description for the Principal Scientist, Compound Management position at Loxo Oncology?
About Loxo@Lilly:
Loxo@Lilly aims to create medicines that make life better for all those affected by cancer around the world. Bringing together the focus and spirit of a biotech with the scale, resources, and heritage of Lilly, our team is focused on rapidly delivering impactful new medicines for people with cancer. Our approach centers on creating oncology medicines that unequivocally show early signs of clinical activity and will matter to patients. We intend to curate a balanced pipeline of medicines, either internally or externally discovered, with the potential to treat cancer with dramatic effect. Loxo@Lilly was created in December 2019, combining the Lilly Oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. Loxo@Lilly is a global organization with team members in Louisville, Colorado; Indianapolis, Indiana; New York City, New York; San Diego, California; South San Francisco, California; Stamford, Connecticut; and Madrid, Spain.
The Principal Scientist, Compound Management will work closely with leadership and team members to help operationalize and maintain a compound management operation. This team will be accountable for establishing and executing SOPs and processes related to storage of inventory, preparation of samples for testing, and shipping/receipt of supplies/samples/compounds for internal/external assays. This role will support compound management activities across multiple geographies, multiple departments and external CROs.
Roles and Responsibilities of the Position:
- Assist in implementation of recently purchased capital equipment for expansion of the compound management operation and implement plans for long term, sustainable instrument maintenance.
- Maintain and improve sample workflows associated with storage, manual neat/weigh operations, liquid handling, and delivery of samples to internal and external teams.
- Provide compound registration support.
- Develop tools to simplify internal processes and improve user experience.
- Manage processes associated with international and domestic shipments between collaborators and research sites, ensuring proper documentation is maintained.
- Establish/Maintain a generative safety culture and ensure adherence to safety policies.
- Serve as a steward for the physical compound inventory as well as the associated inventory/output data.
- Test/Validate changes to software, hardware, and procedures. Proactively seek improvements to usability of these systems and production timelines.
- Create and maintain SOPs and job aids for critical processes.
- Troubleshoot software and hardware issues and resolve sample dispensing issues raised by customers.
- Assist laboratory technicians with day-to-day responsibilities, ensuring projects are supported in a timely, consistent manner.
- Establish processes for replenishment of consumables.
- Track production metrics to quantify required changes and subtle operational issues.
- Continue customization of sample software, and work closely with vendors to solve problems.
- Maintain effective oral and written communication to Discovery team members and provide support to ensure timelines are met.
- Maintain customer-focused attitude and operation.
- Provide additional support to the Discovery Team as requested.
Required Qualifications and Preferred Background:
- Required:
- BS/MS or equivalent degree in chemical, biological, engineering sciences or related field with 5 years working full time in a laboratory setting either in academia or industry.
- Experience programming and maintaining laboratory instruments/automation related to compound management (e.g., storage systems, balances, traditional and acoustic liquid handlers)
- Experience maintaining an inventory of neat and solubilized samples.
- Experience with inventory/request database systems for compound and/or biological sample management (LIMS).
- Experience with software and hardware components of relevant automation platforms such as Beckman Echo, Tecan, High Res Biosystems, and automated storage (Hamilton and/or Azenta)
- Experience with automation controlling software such as Cellario, Green Button Go or similar.
- Experience scripting in any relevant languages
- Experience shipping/receiving both domestically and internationally.
- Strong organizational skills and attention to detail.
- Ability to work both independently and within a multidisciplinary team.
- Excellent written, verbal, and interpersonal communication skills are required, with ability to work with/across a range of disciplines including biology, medicinal chemistry and bioassay.
Ideal candidate will also have:
Loxo@Lilly currently anticipates that the base salary for the Principal Scientist level position could range from between $$90,000 to $132,000, and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position will also be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described.
Physical Demands/Travel:
The physical demands of this job are consistent with working in a lab. This job requires the ability to lift up to 25 lbs.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment:
This position’s work environment is in a lab.
The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.
To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
Loxo@Lilly (Eli Lilly and Company) is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).
Loxo@Lilly (Eli Lilly and Company) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email loxoaccommodation@loxooncology.com for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.
Salary : $90,000 - $132,000
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