What are the responsibilities and job description for the Senior Director, US Commercial Strategy and Operations Planning position at Madrigal Pharmaceuticals?
About Madrigal:
Madrigal is a biopharmaceutical company pursuing novel therapeutics for non-alcoholic steatohepatitis (NASH), also known as metabolic dysfunction associated steatohepatitis (MASH). Our first therapy, Rezdiffra (resmetirom), was granted accelerated approval by the U.S. Food and Drug Administration (FDA) for the treatment of adults with NASH with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis) and is being studied in a Phase 3 trial for the treatment of NASH with compensated cirrhosis.
Role Overview:
Senior Director, US Commercial Strategy and Operations Planning
We are seeking dynamic and experienced Senior Director of US Commercial Strategy and Operations Planning to join our CS&O leadership team. This role combines strategic planning with operational oversight with cross-functional leadership coordination to ensure the seamless execution of key US commercial initiatives. The successful candidate will act as a trusted advisor to the commercial team, driving strategic initiatives, aligning cross-functional teams, and optimizing operational excellence at Madrigal. The role also focuses on fostering a culture of innovation and monitoring emerging trends to maintain competitive advantage.
Position Responsibilities:
Base salary is determined by several factors that include, but are not limited to, a successful candidate's qualifications, skills, education, experience, business needs, and market demands. The role may also be eligible for bonus, equity, and comprehensive benefits, which include flexible paid time off (PTO), medical, dental, vision, and life and disability insurance.
Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.
Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.
Please be aware that we are currently receiving numerous reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Interviews with Madrigal are conducted via the Zoom platform.
Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for Madrigal we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks.
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Madrigal is a biopharmaceutical company pursuing novel therapeutics for non-alcoholic steatohepatitis (NASH), also known as metabolic dysfunction associated steatohepatitis (MASH). Our first therapy, Rezdiffra (resmetirom), was granted accelerated approval by the U.S. Food and Drug Administration (FDA) for the treatment of adults with NASH with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis) and is being studied in a Phase 3 trial for the treatment of NASH with compensated cirrhosis.
Role Overview:
Senior Director, US Commercial Strategy and Operations Planning
We are seeking dynamic and experienced Senior Director of US Commercial Strategy and Operations Planning to join our CS&O leadership team. This role combines strategic planning with operational oversight with cross-functional leadership coordination to ensure the seamless execution of key US commercial initiatives. The successful candidate will act as a trusted advisor to the commercial team, driving strategic initiatives, aligning cross-functional teams, and optimizing operational excellence at Madrigal. The role also focuses on fostering a culture of innovation and monitoring emerging trends to maintain competitive advantage.
Position Responsibilities:
- US Key Strategic Initiatives
- Collaborate with commercial leadership to develop and refine key strategic initiatives that support market expansion and revenue growth
- Act as a trusted advisor to the Head of Commercial Strategy & Operations, providing thought leadership and operational support to align initiatives with business objectives
- Analyze market trends, competitive landscapes, and customerneeds to identify opportunities and mitigate risks
- Monitor the execution of key initiatives, ensuring accountability, and provide regular updates to senior leadership
- Prepare briefing materials, reports, and presentations for executive leadership and board meetings
- US Operational Planning and Execution
- Design and implement operational plans to support strategic goals, ensuring alignment with sales, marketing, market access, and medical affairs
- Oversee the development of resource allocation frameworks and KPIs to drive data-informed decision-making
- Partner with finance to develop budgets and ensure resource optimization
- Facilitate the execution of strategic priorities by coordinating across functional teams and removing barriers to success
- Innovation and Continuous Improvement
- Champion knowledge-sharing practices to bridge gaps and improve integration between commercial functions
- Encourage and support innovative ideas and initiatives within teams to improve processes, strategies, and outcomes
- Identify and address operational inefficiencies, driving continuous improvement across commercial functions
- Stay ahead of industry trends, technologies, and regulatory changes to proactively adapt strategies and operations
- Develop platforms and forums for knowledge sharing, creative problem-solving, and fosterinnovation across teams
- Education: Bachelor’s degree in Business, Life Sciences, or a related field required; MBA or advanced degree preferred
- Experience:
- Minimum of 12-15 years of experience in commercial operations, commercial strategy & insights, commercial data and analytics, or a related field, with a significant portion in the pharmaceutical or biotechnology industry
- Proven track record of leading successful product launches, high-impact initiatives, and cross-functional teams in a complex, regulated environment
- Skills:
- Strong analytical and strategic thinking skills with a results-driven mindset
- Exceptional leadership, communication, and influencing abilities
- Expertise in resource planning, performance management, and operational execution
- Familiarity with CRM systems, data analytics tools, and industry-specific platforms
- Strategic vision and ability to translate complex concepts into actionable plans
- Exceptional organizational and problem-solving skills with the ability to manage ambiguity
- High emotional intelligence and aptitude for building strong relationships across diverse teams
- Proven ability to manage competing priorities while maintaining a focus on organizational goals
- Strong collaborative mindset with the ability to integrate and align multiple commercial functions
- Embraces innovation as a core value, encouraging teams to think creatively and explore transformative opportunities to drive growth and efficiency
- Business Owner Mindset: Demonstrates accountability, ownership, and a proactive approach to achieving results, while consistently seeking ways to innovate and deliver value
Base salary is determined by several factors that include, but are not limited to, a successful candidate's qualifications, skills, education, experience, business needs, and market demands. The role may also be eligible for bonus, equity, and comprehensive benefits, which include flexible paid time off (PTO), medical, dental, vision, and life and disability insurance.
Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.
Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.
Please be aware that we are currently receiving numerous reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Interviews with Madrigal are conducted via the Zoom platform.
Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for Madrigal we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks.
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