Program Team Lead, Cardiovascular Outcomes

About the Company

Marea Therapeutics is a clinical-stage biotechnology company based in San Francisco with a

growing pipeline of first-in-class therapies to address genetically validated cardiometabolic

disease targets. Our therapies have the potential to complement existing therapies and serve as

transformative treatment options for significant patient populations living with cardiometabolic

diseases.

Incubated by Third Rock Ventures, Marea completed a Series B financing in June 2024 and is

now well funded by a syndicate of leading life science investors including Sofinnova, Forbion,

Xontogeny/ Perceptive Advisors, venBio, Omega Funds, Surveyor, Alpha Wave and Third Rock

Ventures. The company’s lead program is in Phase 2 clinical development (MAR001) and a

second program is progressing towards clinical development in a rare cardiometabolic disease.

MAR001 is a first-in-class program targeting inhibition of ANGPTL4, and has the potential to

become a new therapeutic to address the subset of patients at highest risk of adverse CV

events despite current standard of care therapies. We are building the MAR001 team to rapidly

progress the molecule through Phase 2 clinical studies and into a registrational Phase 3 CV

outcomes study. Marea is a fast-growing company looking for extraordinary individuals to join

our team who want to make a difference in the lives of millions of people living with

cardiometabolic diseases. The company is led by a dynamic team of scientists and company

builders with deep knowledge and experience in cardiometabolic diseases, human genetics,

and adipocyte biology.

At Marea, we believe in the power of collaboration and the importance of leading by example.

We are a tight-knit team that values the contributions of every member, from interns to senior

leaders. Our environment is dynamic, with each day presenting new challenges and

opportunities for growth. Every role is “Hands-On”, and the successful candidate will be able to

work alongside team members, regardless of level, to understand challenges and drive results.

About the Role

As the Program Team Lead for MAR001 you will be the “CEO” of the molecule, responsible for

leading a cross-functional program team to develop clinical development strategies to maximize impact and value and to monitor and ensure execution, risk mitigation and appropriate resourcing. This is not a project management role, this is a high profile role for a strategic leader. You will spearhead the planning, coordination, and execution of cardiovascular

projects, ensuring they meet both scientific and clinical objectives. You will lead a cross-

functional team to maximize the impact and value of MAR001 by developing strategies and

executing on clinical development, scientific communication, and commercial/market planning.

You will lead a team that includes representatives of Research, Development, Commercial,

Finance, Regulatory and Manufacturing to ensure alignment with the companys goals. This role

is critical to advancing our mission of delivering groundbreaking therapies to improve outcomes

for patients with cardiometabolic conditions.

This is a FTE position with the expectation of coming into the SF-based office a minimum of

three days / week.

Responsibilities

• Lead the Program Team for our lead asset MAR001, ensuring alignment with strategic goals and timelines.
• Partners with the Project Manager and all Functional Leads to develop program strategies and ensure optimal execution of the plan.
• Develop and implement program plans, milestones, and deliverables, monitoring progress and mitigating risks to ensure timely and cost-effective completion.
• Provide direction and leadership to the project team members to ensure objectives are clear and risks are effectively managed/escalated.
• Partner with key stakeholders to develop project vision, strategy, product evaluation, product scope, project milestones, risk assessment and management strategies, as well as project investment requirements. Project Teams typically include representation from Research, Development, Commercial, Finance, Regulatory and Manufacturing.
• Accountable for budgets, timelines, and resources for projects, adjusting as necessary to meet evolving program needs.
• Drive team adherence to industry best practices, regulatory standards, and company policies to maintain the highest quality and compliance standards.
• Present project updates and strategic recommendations to senior leadership, supporting informed decision-making for ongoing and future programs.
• May present the Program to the Board of Directors or externally.

Qualifications

• Advanced degree (PhD, MD, or equivalent) in a relevant scientific discipline with functional experience in late development or commercial.
• 10 years of industry experience in drug development including leading project teams through late stage development and BLA/NDA, preferably including programs in cardiometabolic indications.
• Proven experience leading cross-functional project teams through complex phases of drug development, preferably in both large and small biopharma settings.
• Familiarity with pre-clinical and clinical regulatory requirements and compliance standards for cardiovascular studies.
• Strong problem-solving skills, with the ability to anticipate challenges and implement effective solutions.
• Strong decision-making and analytical skills.
• Excellent communication, influencing and leadership abilities to foster collaboration and
• motivate diverse teams and to enable decision-making by senior leadership.
• Ability to tailor communication to audiences across disciplines and experience levels.
• Able to flexibly move from a holistic, high level strategic perspective to a detailed functional level as needed.
• Able to assess Program Team capabilities across all program tam disciplines, and highlight gaps or areas of risk to program deliverables.
• Mentors and coaches team members as needed to promote optimal performance and execution of deliverables across the Program Team.
• Must be science- and data-driven and have the highest personal values and ethical standards.
• Flexibility and adaptability to work under pressure in a fast-paced early biotech environment with tight deadlines.
• Highly motivated, proactive, enthusiastic and goal orientated.

WORKING CONDITIONS

• Prolonged periods of being at a stationary desk or work computer.
• Ability to occasionally adjust, handle, or move objects up to [20] pounds.
• Assessing the accuracy, neatness, and/or thoroughness of the work assigned.
• Communicating with others to exchange information.
• Occasional travel as required to meet business objectives.

We do not discriminate on the basis of race, color, religion, sex, sexual orientation, gender

identity or expression, national origin, age, disability, veteran status, marital status, or based on

an individual’s status in any group or class protected by applicable federal, state, and local law.

We invite applications from minorities, women, the disabled, protected veterans and all other

qualified applicants.

The anticipated salary range for this position for candidates who will work in San Francisco, CA

is $242,000 to $315,000. The final salary offered to a successful candidate will be dependent on

several factors that may include but are not limited to the type and length of experience within

the job, type, and length of experience within the industry, education, etc.