What are the responsibilities and job description for the Senior Scientist, Biology position at Mariana Oncology?
Description
We are seeking a Senior Scientist, Biology to support the discovery of peptide ligands to specific cancer drug targets using mRNA display platform.
Illustrative Breadth Of Responsibilities
We are seeking a Senior Scientist, Biology to support the discovery of peptide ligands to specific cancer drug targets using mRNA display platform.
Illustrative Breadth Of Responsibilities
- Design and execute biochemical and cellular experiments to characterize binding activities of radio-peptide ligands to cancer targets. High comfort level working with different kinds of radioemitters is a must.
- Support hit-lead optimization efforts by screening compounds in a radiolabeled binding assay using cancer cell lines, as well as intellectually contribute towards the screening cascade strategy design.
- Support internal and external mechanistic biology efforts to understand cell signaling impact of targeting specific cell surface proteins in cancer cell lines.
- Interpret and analyze data, prepare, and review IND-enabling study reports, communicate findings to project teams, stakeholders, and external collaborators.
- Master’s degree in Biology, Cell or Molecular Biology, Biotechnology, or a closely related scientific field.
- 5 years of drug discovery research experience within the biotech or pharmaceutical industries, including:
- 2 years of experience with mRNA display and in vitro translation of unnatural amino acids;
- 5 years of cell-based assay development using techniques including Flow cytometry (MACSQuant platform), live-cell imaging using Incuctye platform, protein quantification/characterization by western blot and ELISA;
- 2 years of experience handling multiple types of radioisotopes to support in vitro assay development; and
- 3 years of IND enabling/post-IND experience.
