What are the responsibilities and job description for the Oligonucleotide Analytics Scientist position at Mason-Grey Corporation?
POSITION: Oligonucleotide Analytics Scientist
POSTING: 69485 (JNJNJP00069485)
LOCATION: La Jolla / San Diego CA Area (ONSITE)
COMPENSATION: The hourly rate is a maximum range of $48.00 to $52.00. This will annualize to an estimated range of $96,000 to $104,000 based on 40 hour work weeks and 50 of 52 working weeks per year. OT is payable at 1.5X base rate and will add to the overall compensation based on actual hours worked.
JOB DESCRIPTION/EXPERIENCE: Oligonucleotide Analytics Scientist
- Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
- Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis
- Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
- Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
- Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography. Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization.
- Support integrity confirmation requests (such as concentration) by assay development and biology teams
- Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
- Ensure the supply of laboratory consumables and reagents are in stock as needed
- Maintain a high level of productivity in the laboratory setting.
- Present data and reports on project status at individual, group, and departmental meetings.
Qualifications:
- Ph.D.. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required.
- Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required.
Top Three Skills:
- Operate LC-MS systems
- Analyze and optimize methods
- Establish and automate high throughout analytical capabilities
All candidates shall be legally authorized to work in the US and are subject to background screening, drug testing and verification of legal status in the United States using eVerify.
Salary : $48 - $52
