What are the responsibilities and job description for the Oligonucleotide Scientist position at Motion Recruitment?
Our client, a well known pharmaceutical manufacturer is urgently looking to hire a Scientist ON SITE in San Diego, CA!
This is a 12 month contract to hire on W2 offering a full benefits package
Required Skills & Experience
Must have PHD
1-2 years of experience
Experience with Oligonucleotide analytics
siRNA experience a MUST
LCMS experience
Job Responsibilities
Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis
Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization
Support integrity confirmation requests (such as concentration) by assay development and biology teams
Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
Ensure the supply of laboratory consumables and reagents are in stock as needed
Maintain a high level of productivity in the laboratory setting.
Present data and reports on project status at individual, group, and departmental meetings
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