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Senior Director / Vice President, Pharmacology

Metsera, Inc
New York, NY Full Time
POSTED ON 2/19/2025
AVAILABLE BEFORE 5/17/2025

About Us

We are a growing biotech startup pioneering the development of weight loss therapeutics with the potential to revolutionize the treatment of obesity. Our team is passionate about making a real difference in people's lives, and we're committed to building a collaborative, fast-paced, and fun work environment.

Role Summary

This senior role will entail quantitative pharmacology leadership in the development of next generation of medicines and solutions for obesity and metabolic diseases. The position will be responsible for setting the pre-clinical and clinical pharmacology strategies for Metsera's pipeline and accountable for efficient execution of these strategies. This position will act as the pharmacology lead on program development teams and may ultimately support programs from translational- through to late-stage clinical development in close collaboration with other members of these cross-disciplinary teams. As a quantitative pharmacology leader, this position is expected to inform both the clinical pharmacology and model-informed drug development strategy, and to execute on this strategy through a combination of internal and external resources.

The Impact you will have at Metsera

Reporting to the SVP, Pharmacology, you'll be responsible for :

  • acting as pharmacology lead on cross-disciplinary development teams, ultimately supporting programs from IND-enabling through to late-stage clinical development, and modeling leadership competencies to junior members of the staff
  • setting the quantitative pharmacology and model-informed drug development (MIDD) strategy and defining major deliverables based upon deep understanding of overall strategic objectives of the development team and current regulations, guidelines, and quality standards
  • executing the quantitative pharmacology strategy both in collaboration with internal team leads (e.g. clinical, biostats, toxicology, regulatory, nonclinical and CMC) and with external vendors
  • leading quantitative pharmacology activities through IND and quantitative clinical pharmacology activities for clinical candidates through regulatory submission and beyond
  • engaging in strategic communication with senior leadership and external stakeholder networks to influence outcomes

What you bring to Metsera :

Required :

  • M.D., Pharm.D., and / or Ph.D. in pharmacology, pharmacokinetics, engineering, or related discipline with 10 years of post-doctoral experience in relevant technical area
  • proven success in quantitative pharmacology strategy and execution, with multiple examples of successful application of MIDD
  • demonstrated experience in planning, designing, implementing, and analyzing clinical pharmacology studies
  • working knowledge of health authority and regulatory guidelines for drug development
  • familiarity with bioanalytical and translational sciences
  • authorship of relevant sections of clinical and regulatory documents (e.g., clinical protocols, IBs, CTDs, INDs, NDAs, IMPDs, and briefing books)
  • experience in budget planning and management of external CROs and consultants
  • excellence in strategic oversight and stakeholder management
  • strong leadership experience in multi-disciplinary, collaborative teams
  • the ability to work collaboratively as part of a team in a fast-paced dynamic environment
  • strong verbal and written communication skills, and ability to explain methodology and consequences of decisions in lay terms
  • leadership skills in proactive strategy setting, priority evaluations, adapting to changes, conflict resolutions, and effective partnership
  • adept at challenging the status quo and championing innovative solutions
  • Preferred :

  • experience in therapeutic peptide development and / or obesity and metabolic disease therapeutic area
  • hands on modeling experience
  • Metsera is an equal opportunity employer. We welcome all qualified applicants and celebrate diversity in our mission to develop groundbreaking medicines.

    Pay Transparency Disclosure : The expected salary range for this position is $200,000 - $307,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

    Salary : $200,000 - $307,000

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    Job openings at Metsera, Inc

    Metsera, Inc
    Hired Organization Address New York, NY Full Time
    About Us We are a growing biotech startup pioneering the development of weight loss therapeutics with the potential to r...

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