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Vice President, Clinical Operations

Neomorph, Inc.
San Diego, CA Full Time
POSTED ON 2/20/2025
AVAILABLE BEFORE 5/18/2025

Neomorph is growing and is seeking a Vice President / Head of Clinical Operations to lead and execute clinical operations, with an initial focus on early-phase clinical trials in Oncology. This role is ideal for a collaborative and experienced leader with a deep understanding of clinical trial execution, particularly in Oncology Phase 1 / 2 trials, and a background in small biotech or start-up environments.

The successful candidate will oversee all operational aspects of clinical trial initiation and execution, including clinical CRO and associated vendor management, trial site coordination, regulatory compliance, and study execution. This role requires a proactive, strategic thinker who can balance high-level planning with hands-on execution in a fast-moving and dynamic biotech setting.

This is an onsite position based at our site in San Diego.

Key Responsibilities :

  • Develop and lead clinical operations strategy and execution for early-phase clinical trials.
  • Oversee clinical CRO selection, contract negotiation, and performance management, ensuring cost-effective and high-quality study execution.
  • Lead trial start up, site selection, patient recruitment, and study monitoring, ensuring trials meet recruitment goals and integrated timelines.
  • Serve as the primary liaison with clinical sites and external vendors, fostering strong partnerships for seamless trial execution.
  • Partner with clinical development, program leadership, and external regulatory and CMC consultants to support trial execution and compliance.
  • Ensure clinical operations alignment with IND submissions and regulatory requirements, including preparation for regulatory inspections.
  • Develop and refine protocols and operational processes to optimize first-in-human (FIH) and early-phase trials.
  • Establish best practices and processes to scale clinical operations as the company grows.
  • Maintain compliance with GCP guidelines and global regulatory standards across all clinical activities.
  • Work closely with the finance team for study cost budget forecasting and review.
  • Work closely with the CMC team (in-house or consultants) to ensure clinical trial supply readiness.

Qualifications :

  • 10 years of experience in clinical operations, with a strong focus on US-based clinical trials.
  • Extensive experience managing Phase 1 trials and leading early-phase clinical operations.
  • Proven ability to lead clinical operations in a small biotech or start-up environment, balancing strategic oversight with hands-on execution.
  • Experience collaborating with internal or external CMC partners to ensure clinical trial supply readiness.
  • Demonstrated success in managing clinical CROs and external vendors, ensuring efficient and high-quality trial execution.
  • Strong understanding of global regulatory requirements, GCP guidelines, and clinical trial operations.
  • Strong understanding of clinical trial cost, budgets, and accounting requirements.
  • Ability to build, scale, and optimize the clinical operations function as the company evolves.
  • Excellent leadership, problem-solving, and cross-functional collaboration skills.
  • What we offer :

  • Industry competitive compensation
  • Annual target bonus
  • Stock options
  • 401K plan
  • Career advancement opportunities
  • Monthly town halls to share business and scientific updates
  • Work Hard, Stay Well

  • Comprehensive medical, dental, and vision plans for employees and their dependents
  • Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
  • Employee Assistance Program
  • 10 holidays Winter Shutdown 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
  • Supplemental pay for Pregnancy Disability Leave
  • Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care
  • Lifestyle

  • Casual work environment
  • Volunteer days off each year to spend time contributing to causes you care about
  • Flexible work schedule
  • Access to onsite gym
  • Onsite space to store your bicycle (or surfboard)
  • Have Fun!

    We believe in work / life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).

    About Us :

    Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against 'undruggable targets'. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment.

    Neomorph is headquartered in San Diego, California.

    Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law.

    Notice to agencies : Neomorph will not accept unsolicited assistance from recruiting / search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and / or method without a valid written search / recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.

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