Vascular Scientist

Position Summary

This position offers the opportunity to work in a multidisciplinary team on cutting-edge technologies at the intersection of disease relevant cell biology, genome engineering, massively parallel high-content single-cell screening and machine learning. This role will spearhead the team's efforts in designing and developing novel functional high-throughput CRISPR screening techniques and assays, as well as being part of the team’s effort to perform novel single-cell RNA sequencing applications. This role will require close collaboration with the wet-lab R&D team for data-driven refinement of experimental designs and new method development. The successful candidate will be an excellent team player and communicator who can thrive in a fast-paced startup environment.

Key Responsibilities

• Develop, optimize, and validate cellular and biochemical assays to support target identification, confirm mechanism of action and enable lead optimization.  
• Design, execute, and analyze in vitro experiments to evaluate pharmacological properties of potential therapeutic leads across modalities including small molecules, biologics, genetic and cell-based therapies
• Perform cell culture, including primary cell isolation and maintenance of cell lines, to support diverse project needs
• Analyze, interpret and communicate results and import of experimental data to inform project strategies and drive decision-making
• Author detailed experimental protocols, technical reports, present findings at internal meetings and external scientific conferences
• Develop plans for in vivo experiments

Qualification and Education Requirements

You must have:

• PhD in Cell Biology, Pharmacology, Molecular Biology, or related field with 2 of relevant industry experience
• Proven track record of developing and running translational In vitro models (e.g., viability, signaling, and functional assays) as a part of comprehensive pharmacological profiling
• Proven track record in cardiovascular biology, lung disease and or kidney disease
• Proficiency in molecular and cellular biology techniques, including but not limited to flow cytometry
• Knowledge of pharmacological principles (e.g., potency, efficacy, and kinetics) and computational tools as applied to drug discovery and development (e.g., screening methodology using single-cell and bulk data, dose-response and PK/PD analysis, etc.)
• Strong problem-solving ability and aptitude for innovation
• Adaptable/Flexible and able to prioritize and work across multiple projects in parallel while delivering high-quality, detail-oriented results in a timely manner
• High degree of teamwork and collaborative attitude are essential
• Ability to work independently

Additional preferred experience includes:

• Experience with in vivo models
• Previous experience managing both internal work and outsourced work at CROs
• Experience with high-throughput screening and CRISPR

At Neptune Bio, we are committed to matching our new hires to the level that best fits with the experience they bring with them. For this job, the levels we will hire at are:

• Scientist II: $120,000-$140,000
• Senior Scientist: $140,000-$160,000