What are the responsibilities and job description for the Scientist I - Oligonucleotide Synthesis position at Novo Nordisk?
Scientist I - Oligonucleotide Synthesis
Facility: Research
Location:
Lexington, MA, US Lexington, MA, US Lexington, MA, US
About the Department
The Global Nucleic Acid Therapies area strives to be a global leader in nucleic acid therapeutics by developing innovative technology platforms and molecules that translate into novel genetic medicines to improve patients' lives.
Our mission is to bring curative and disease modifying therapies to individuals living with serious chronic conditions. We are a global team with locations in Massachusetts (Greater Boston Research & Early Development Hub), Colorado and Copenhagen, pushing technological innovation to expand the RNA and gene therapy application space. Our proprietary GalXC™ and GalXC-Plus™ RNAi technologies have the potential to address conditions that are difficult or impossible to treat with other modalities. The value chain spans from early research to phase 1 clinical studies.
Established as a Transformational Research Unit (TRU), Global Nucleic Acid Therapies is a unique organization within Novo Nordisk Research & Early Development that brings together the best of both worlds – the agility, collaborative pioneering spirit and calculated risk-taking profile of a biotech along with the scale, resources and capabilities of a global leader in drug development. We are a team of inventive and entrepreneurial thinkers pushing the boundaries of science. Together, we are driving change. Are you ready to make a difference
The Position
Novo Nordisk is seeking a highly motivated scientist to join its oligonucleotide chemistry team in Lexington, Massachusetts. The candidate will be responsible for the synthesis and analysis of oligonucleotides. This position will support therapeutic programs in multiple disease areas and will contribute to the development of novel nucleic acid conjugate platforms. Prior experience in oligonucleotide synthesis and characterization is desired.
Relationships
This position reports to the Director, Oligonucleotide Chemistry.
Essential Functions
- Synthesis of oligonucleotides, deprotection, purification, annealing and lyophilization of oligonucleotides to support all disease programs
- Analytical characterization of the synthesized oligonucleotides for purity determination and impurity profiling
- Support new chemistry discovery for the development of novel oligonucleotide conjugate platforms
- Operate, maintain, and troubleshoot lab instruments such as oligonucleotide synthesizers, purification systems, HPLC and LC-MS
- Conduct laboratory work in safe, efficient manner that ensures a safe working environment for colleagues
Physical Requirements
0-10% overnight travel required.
Qualifications
- PhD in Organic Chemistry with 0-2 years of industrial experience, or MS with at least 3 years of industrial experience, or BS with 5 Years
- Strong knowledge of nucleic acids chemistry, oligonucleotide synthesis, deprotection and purification techniques
- Experience with oligonucleotide synthesizers preferred
- Experience with synthesis, purification, and analysis of sgRNA preferred
- Experience with analytical techniques e.g. RP-UPLC, SAX-HPLC, LC-MS and data interpretation
- Ability to complete assignments and meet deadlines and time schedules
- Keep accurate record of the experiments and summarize the results in written reports
- Possess excellent written and verbal communication skills
- Demonstrate an ability to work as part of a team and possess an excellent work ethic
- Ability to be successful in a fast-paced, intense work environment
We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.
At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.
Novo Nordisk is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations.
If you are interested in applying to Novo Nordisk and need special assistance or an accommodation to apply, please call us at 1-855-411-5290. This contact is for accommodation requests only and cannot be used to inquire about the status of applications.
