What are the responsibilities and job description for the Senior Scientist, Translational Medicine position at Nuvalent, Inc.?
The Company : With deep expertise in chemistry, Nuvalent is working to create selective medicines designed with the goal to address the needs of patients with cancer. Nuvalent is an exciting early-stage company, bringing together experienced scientists and industry veterans with a proven track record in drug discovery, oncology drug development, and company building.
The Role :
Reporting to the Senior Director, Translational Medicine, the Senior Scientist, Translational Medicine will be a part of a fast paced, dynamic, growing team on the leading edge of oncology drug discovery. We seek a Senior Scientist, preferably in the greater Boston area, with expertise in translational biology / biomarker and bioinformatics to contribute across our developmental programs. Working closely with the development team, biology team and external labs / CROs / academic collaborators, the Senior Scientist will participate in and lead cross-functional teams to contribute to the development and execution of an innovative biomarker strategy that addresses patient selection, mechanism of action, pharmacodynamics, and predictive biomarkers of response and resistance.
Responsibilities :
- Lead the generation, analysis, and documentation of clinical biomarker data, including next generation sequencing with tissue and plasma samples, gene expression profiling, and histopathology assays
- Conduct in-depth analysis and interpretation of biomarker data including in the context of other types of clinical data, and present findings in internal meetings
- Overseeing activities at contracting clinical translational biomarker labs
- Oversee nonclinical translational biology studies, including monotherapy and / or combination studies in disease relevant models in CROs and collaborating labs
- Work closely with clinical operations and sample management to oversee activities at central labs and contribute to implement / improve sample strategy
- Effectively collaborate across internal functions including biology, clinical operations, clinical pharmacology, clinical science, data management, sample management, statistics, and quality, to ensure successful execution in the clinic
- Represent Translational Medicine within a cross functional multi-disciplinary clinical study team, provide biomarker / scientific support, to meet project milestones for translational medicine responsibilities
- Contribute to the development of clinical protocols, laboratory manuals, regulatory submissions; lead or contribute to the development of abstracts, external presentations, and publications
Competencies :
Qualifications :
Nuvalent provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.
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