What are the responsibilities and job description for the Senior Research Associate, Analytical Development Contractor (Core Testing/Characterization) position at Obsidian Therapeutics?
Senior Research Associate, Analytical Development Contractor (Core Testing / Characterization)
Bedford, MA
About Us…
Obsidian Therapeutics is expanding the reach of TIL therapy. We are pioneering engineered tumor infiltrating lymphocyte (TIL) therapies to deliver transformative outcomes for patients suffering from solid tumor malignancies. Obsidian’s programs apply our cytoDRiVE® platform technology to express regulated therapeutic proteins to enhance anti-tumor activity. We are investigating OBX-115 and enrolling patients in an ongoing multicenter clinical trial in advanced melanoma and non-small cell lung cancer ( Agni-01 ).
We’re proud of our diverse talented team and committed to cultivating an environment where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. Our research team is based in the heart of Cambridge, MA, and our Technical Development, Manufacturing & Quality team is based in our facility in Bedford, MA. Obsidianites enjoy a highly collaborative culture, competitive salary and benefits, and potential for ownership through stock options.
In April 2024, we announced closure of an oversubscribed $160.5 million Series C financing with a top-tier syndicate of life science investors to advance Obsidian’s lead program in its ongoing trials.
Our Opportunity…
We’re looking for a highly motivated scientist with experience in primary human cell culture, molecular analytics, and cell-based assays to work with our Analytical Development Core Testing team. You’ll focus on characterizing engineered cell therapy products and supporting Obsidian’s tumor infiltrating lymphocytes (TIL), viral vector and critical materials analytical teams. You’ll support critical studies and experiments to advance Obsidian OBX-115 product understanding and work with various subject matter experts across different functional groups, affording a significant learning opportunity and career development. This position is a six month contract role.
As part of our Technical Development, Manufacturing, and Quality group based in our Bedford, MA location, you'll be a vital part of a highly collaborative team working to achieve the Obsidian’s vision by translating innovative science into medical breakthroughs for patients, starting with our lead program cytoTIL15 a novel engineered tumor-infiltrating lymphocyte (TIL) therapy. This is a unique opportunity in a well-funded clinical stage company with blue chip investors, field-leading advisors, and a highly experienced leadership team. You’ll be part of a dynamic, collaborative, innovative, passionate, patient-focused, and successful organization focused on delivering transformative therapies in areas of greatest clinical need.
You Will…
- Collaborate with team leaders to characterize cell-based products and raw materials (i.e., viral vector and irradiated feeder cells) using molecular and cell based analytical methods.
- Execute test methods, troubleshoot assays, analyze and discuss data, and communicate findings / present results at internal meetings.
- Develop the technical and analytical skills needed to support product characterization, including but not limited to : TIL analysis using multi-parameter flow cytometry, monitoring product impurities using flow cytometry and molecular biology tools like ddPCR and ELISA.
- Author and review technical methods and reports.
- Maintain accurate and timely record keeping in ELN.
- Support lab functions including maintaining reagent supplies, restocking consumables, lab organization, sample inventory management, etc.
- Make intellectual and technical contributions to projects.
- Maintain a safe work environment in accordance with policies / procedures / regulations.
You Bring…
Core Qualifications
Bonus Qualifications
Obsidian is proud to be an equal opportunity employer, cultivating a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.
