BioAnalytical Scientist

Pinetree Therapeutics, Inc. is a biotech startup developing bispecific antibodies for cancer therapy. Our mission is to deliver on the promise of therapeutic antibodies to treat drug resistant cancers and immune disorders and create the next generation of transformative medicines for patients. We are a group of highly motivated, dedicated professionals working collaboratively in a multi-facetted team with the ultimate goal to improve patient care.

Pinetree Therapeutics is located near Fresh Pond in West Cambridge, convenient to public transportation. If you are looking to join a dynamic team serving this ever-important mission, then Pinetree is the place for you!

The Role

We are seeking a dynamic and innovative Scientist to join our team and who is dedicated to pioneering the discovery and development of targeted antibody-based receptor protein degraders to treat a broad range of solid tumor cancers. This individual will work in cross-functional teams to provide bioanalytical method development and PK and ADA sample analysis to help identify and develop novel therapies to treat targeted patient papulations within multiple oncology indications. She/he will lead efforts in developing cutting edge MSD and/or ELISA-based methodologies. The role requires a blend of expertise in method development and sample analysis, and a passion for research to drive our mission of delivering breakthrough therapies to patients.

Duties and Responsibilities:

●      Primary responsibility will be to support our Protein Discovery group by performing high-throughput screening ELISA/MSD assays to aid in identifying lead candidates for our drug development pipeline.

●      Independently design and develop ELISA/MSD based assays/methodologies for use in screening assays, analyze serum samples for drug and anti-drug antibodies resulting from discovery, and non-GLP PK/PD, PK, and Toxicology studies, and develop complex strategies and enable the advancement of Company objectives.

●      Perform quantitative bioanalytical immunoassay experiments to support non-regulated pharmacokinetic (PK) analyses of biotherapeutic drug candidates and evaluate anti-drug antibody (ADA) response.

●      Facilitate assay transfer activities in collaboration with external CROs for assay validation in compliance with regulatory guidelines.

Growth Opportunities:

●      Support the development of regulated and clinical bioanalytical strategies for large molecule drug candidates and conduct PK, ADA, and biomarker assays internally.

●      Contribute to outsourcing of non-GLP, GLP, and GCLP clinical BA assays.

●      Review and edit GLP and clinical BA assay validation protocols, and reports.

●      Review and evaluate immunoassay bioanalytical results supplied by external CROs to ensure quality; review GLP and clinical BA assay validation protocols and reports.

●      Prepare bioanalytical method summaries to support preparation of study reports and relevant sections of regulatory IND/CTA filings

Qualifications

●     PhD in Biochemistry, Analytical Chemistry, Pharmacokinetics, or related scientific discipline, or BS/MS degree with 4 years of biopharmaceutical industry experience.

●      Demonstrated expertise in immunoassay/ligand binding assay techniques for biotherapeutic quantification in complex biological matrices, preferably using ELISA/MSD technology.

●      Excellent critical thinking and scientific skills, and a demonstrated ability to analyze, interpret, and clearly communicate complex BA data.

●      Ability to work effectively and collaboratively on cross-functional projects teams.

●      Excellent oral, presentation, and written communication skills.

Preferred Skills & Experience:

●       Curiosity and proactive engagement in scientific discussions are essential.

●       Must be fluent in English, both written and spoken.

Opportunity to be at the forefront of oncology research, contributing to the development of next-generation cancer therapies.

A collaborative, supportive, and inclusive work environment where innovation thrives, and career development is encouraged.

Competitive compensation package, including comprehensive benefits and opportunities for professional growth.

Pinetree is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Pinetree will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Recruitment & Staffing Agencies: Pinetree does not accept unsolicited resumes from any source other than candidates. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Pinetree, and Pinetree will not owe any referral or other fees with respect thereto.