Postdoctoral Researcher, Toxicology

Pinetree Therapeutics, Inc. is a biotech startup developing bispecific antibodies for cancer therapy. Our mission is to deliver on the promise of therapeutic antibodies to treat drug resistant cancers and immune disorders and create the next generation of transformative medicines for patients. We are a group of highly motivated, dedicated professionals working collaboratively in a multi-facetted team with the ultimate goal to improve patient care.

Pinetree Therapeutics is located near Fresh Pond in West Cambridge, convenient to public transportation. If you are looking to join a dynamic team serving this ever-important mission, then Pinetree is the place for you!

The Role

We are seeking a dynamic and innovative Postdoctoral Scientist in Toxicology to join our team who is dedicated to pioneering the discovery and development of targeted antibody-based receptor protein degraders to treat a broad range of solid tumor cancers, and would like to gain experience in Toxicology in a drug development in a cutting edge biotechnology company. This individual will work in cross-functional teams to provide Discovery and/or Development Toxicology support to help identify toxicity liabilities that could be encountered in clinical development and develop novel therapies to treat targeted patient populations within multiple oncology indications. She/he will lead efforts in researching potential toxicities related to super-pharmacology and/or off target toxicity. The role requires a blend of expertise in molecular and systems toxicology, a working knowledge of pharmacokinetics, and a passion for research to drive our mission of delivering breakthrough therapies to patients.

Duties and Responsibilities:

• Provide literature reviews and toxicology assessments for current and future pipeline targets to be used in targeted antibody-based receptor protein degraders.
• Design, conduct, and interpret toxicity studies that inform on the mechanism(s) of toxicity, address relevance to humans, and design appropriate tools that can be used to proactively evaluate and predict liabilities associated with bispecific antibodies alone or in combination with small molecule inhibitors and develop complex strategies that enable the advancement of Company objectives.
• Work closely with the Executive Director of Preclinical Development to develop strategies to address specific safety issues and partner with project teams to select and advance development molecules. 
• Participate in the development of assays/methodologies and analyze/quantify serum samples for drug and anti-drug antibodies resulting from PK/PD, PK, and Toxicology studies, desired but not required
• Participate in the planning, design/conduct and oversight of investigative non-GLP and GLP compliant toxicology studies at Contract Research Organizations (CROs) to support regulatory filings leading to drug candidate approval.
• Future growth opportunities include obtaining a thorough understanding of GLP regulations and nonclinical evaluation guidelines across different regulatory landscapes.
• Expansion of responsibilities could also include interacting with Bioanalytical CROs to facilitate assay transfer activities for assay validation in compliance with regulatory guidelines.

Qualifications

• PhD in Toxicology, Pharmacology, Pharmacokinetics, or related scientific discipline
• Thorough understanding of the applicability and limitations of preclinical research and translation to human toxicity and exposure
• Excellent critical thinking and scientific skills, and a demonstrated ability to analyze, interpret, and clearly communicate complex Toxicology and related PK data.
• Ability to work effectively and collaboratively on cross-functional projects teams.

·      Excellent oral, presentation, and written communication skills

Preferred Skills & Experience:

●       Curiosity and proactive engagement in scientific discussions are essential.

●       Must be fluent in English, both written and spoken.

Opportunity to be at the forefront of oncology research, contributing to the development of next-generation cancer therapies.

A collaborative, supportive, and inclusive work environment where innovation thrives, and career development is encouraged.

Competitive compensation package, including comprehensive benefits and opportunities for professional growth.

Pinetree is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Pinetree will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Recruitment & Staffing Agencies: Pinetree does not accept unsolicited resumes from any source other than candidates. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Pinetree, and Pinetree will not owe any referral or other fees with respect thereto.