Postdoctoral Researcher (RNA Biology)

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline includes clinical programs in Duchenne muscular dystrophy, Alpha-1 antitrypsin deficiency and Huntington’s disease, as well as a preclinical program in obesity. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Description

Wave Life Sciences USA seeks a highly motivated postdoctoral research fellow to join its team in Cambridge, Massachusetts. This is an ideal position for an individual with an interest in developing RNA-based therapeutics and who thrives in a team-oriented, fast-paced, and cross disciplinary biotech environment. The main area of focus for the project will be in the forefront of basic research into RNA editing, siRNA and other oligonucleotide technologies. The candidate will be an integral member of a small team of scientists aiming to rapidly and pragmatically realize the potential of a novel oligonucleotide therapeutics platform.

Experience

• Recent or upcoming graduate with a PhD in biochemistry, cell biology, molecular biology or related field
• Experience with mammalian cell culture including transfection, RNA isolation, qPCR, etc.
• Experience in studying RNA biology is desired but not required
• Familiarity with next generation sequencing methods and oligonucleotide therapeutics (antisense, siRNA, exon-skipping, etc.) is a plus

Responsibilities

Will include some or all of the following:

• Work with scientists in the biology team to advance RNA targeting technologies 
• Plan and execute experiments to optimize oligonucleotide design for the purpose of optimizing RNA technologies across multiple different tissue and cell models 
• Rationally apply Wave’s proprietary PRISM platform to improve oligonucleotide efficacy and design
• Execute both in vivo and in-vitro assays to characterize both changes in the RNA editing and gene expression   
• Prepare clearly articulated experimental reports and data presentations
• Attend and contribute to discussions in weekly internal team meetings
• Publish findings in high-quality peer reviewed scientific journals and/or relevant conferences

Key Skills

• Effective communication and interpersonal skills
• Excellent organizational skills with an ability to embrace change and multi-task in an extremely fast paced environment
• Ability to innovate and think creatively to support and advance platform & drug development processes
• Strong presentation skills; adept at presentation of clear and accurate reports for internal and external projects 
• Collaborative and self-motivated team player

Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of Wave Life Sciences’ employees to perform their job duties may result in discipline up to and including discharge.

We value our relationships with professional recruitment firms. To protect the interests of all parties, and given the large volume of inquiries received from third-party placement agencies, we are not able to respond to all agency inquiries. We do not accept unsolicited resumes from any source other than directly from candidates for current or future positions. Submission of unsolicited resumes in advance of a signed agreement between our company and a placement agency does not create an implied obligation and, if an unsolicited candidate represented by a placement agency is hired, we are not obligated to pay a fee. Only approved recruitment firms will be allowed to provide services to Wave Life Sciences, USA.