Scientist

12 Month Contract (May extend or convert to permanent)

$42/hour W2

Top 3 Must Have Skill Sets:

• Experience in evaluation and implementing new technologies to enhance screen capabilities and assay performance for small molecules
• A deep and broad understanding of the development, validation & execution of a wide array of binding & functional activity-based assays such as TR-FRET, FP, PCR etc.
• Excellent organizational, interpersonal and communication skills, along with the ability to work in a flexible team-oriented environment.

Day to Day Responsibilities:

• Contribute to the assay strategies and apply a variety of scientific principles and concepts to the assay design, assay development and troubleshooting in support of small molecule drug discovery.
• Develop and execute biochemical assays and convert into high-throughput screening (HTS) format to enable HTS campaign and meet project goals.
• Apply sophisticated biochemical and biophysical assay techniques to develop and perform potency, kinetic and mechanistic assays for hits validation, compound-target engagement, and SAR study.
• Advance biochemical/biophysical assay screening capabilities and evaluate new assay technologies and experimental approaches using scientific theory and technical literature.
• Strong data analysis capabilities and able to communicate and present research results and provide scientific and technical support.
• Collaborate with internal cross-functional teams and external partners to enable project progression.

Preferred Qualifications

• PhD in pharmacology, biochemistry, molecular biology, or a related discipline.
• Expertise in enzymology, ligand binding kinetics, and mechanism-of-action studies.
• Experience in evaluation and implementing new technologies to enhance screen capabilities and assay performance for small molecules and/or oligonucleotides
• Proficiency in assay development to screen and characterize covalent inhibitors is plus
• Experience with microplate readers such as PerkinElmer Envision and automated liquid handling systems including Multidrop, acoustic dispensers, and digital dispensers.
• Expertise in handling, analyzing and visualizing assay data sets and proficient in software platform such as GraphPad Prism.
• Drug discovery research experience in diverse target classes is a plus but not required.
• Detail-oriented and analytical with excellent problem-solving skills.