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Associate Scientist: Process Chemistry

Proclinical
Cambridge, MA Full Time
POSTED ON 1/19/2025
AVAILABLE BEFORE 4/17/2025

Associate Scientist : Process Chemistry - Contract - Cambridge MA

Proclinical is working alongside a pharmaceutical company seeking an Associate Scientist to join the Process Chemistry join.

Primary Responsibilities :

The successful candidate will be a part of the Process Chemistry group, responsible for the process development and in-house non-GMP manufacture of modified oligonucleotides and siRNAs.

Skills & Requirements :

  • Bachelor's degree in chemistry.
  • Basic understanding of analytical techniques such as pH, osmolality, conductivity measurement, HPLC, and LC-MS.
  • Familiarity with oligonucleotide manufacturing processes, including phosphoramidite chemistry and chromatography, is advantageous.
  • Strong record-keeping and laboratory documentation skills.
  • Commitment to maintaining high laboratory and scientific standards.
  • Ability to maintain a safe, clean, and orderly laboratory environment.
  • Excellent communication skills.

The Associate Scientist : Process Chemistry's responsibilities will be :

  • Support non-GMP oligonucleotide production.
  • Develop, optimize, and scale-up purification methods.
  • Execute non-GMP oligonucleotide purifications.
  • Conduct downstream processing of purified materials.
  • Perform in-process analytical tests.
  • Participate in the creation and review of SOPs and batch records.
  • Assist with campaign activities across various unit operations as needed.
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