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Senior Associate Scientist

Proclinical
Cambridge, MA Full Time
POSTED ON 3/8/2025
AVAILABLE BEFORE 5/12/2025

Senior Associate Scientist - Contract - Cambridge, MA

Proclinical is seeking a Senior Associate Scientist to join our client's team in Cambridge, MA.

Primary Responsibilities :

The successful candidate will focus on lab support and process development for the chemical synthesis and downstream processing of oligonucleotide-based drug substances. This position requires a proactive approach to technical support and optimization of manufacturing processes.

Skills & Requirements :

  • Bachelor's degree in chemistry with laboratory experience, preferably in an industrial setting.
  • Basic understanding and hands-on experience with analytical techniques like pH, osmolality, conductivity measurement, HPLC, and LC-MS.
  • Familiarity with oligonucleotide manufacturing processes, including phosphoramidite chemistry and chromatography, is advantageous.
  • Strong record-keeping skills and adherence to excellent laboratory documentation practices.
  • Commitment to maintaining a safe, clean, and orderly laboratory environment.
  • Effective communication skills and ability to work collaboratively in a dynamic team setting.

The Senior Associate Scientist's responsibilities will be :

  • Provide hands-on lab support for chemical synthesis and downstream processing of oligonucleotides.
  • Conduct synthesis of oligonucleotides up to 11 mmol scale.
  • Perform downstream processing including prep-HPLC, ultrafiltration, annealing, concentration, and lyophilization.
  • Carry out in-process analytical testing such as AX-HPLC, IPRP-HPLC, LCMS, and UV-vis.
  • Offer technical support for optimizing contract manufacturing processes.
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