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Scientist/Senior Scientist, Cell Biology & Assay Development

Rectify Pharma
Boston, MA Full Time
POSTED ON 1/16/2025
AVAILABLE BEFORE 4/13/2025

Job Description

Job Description

Salary :

Rectify Pharmaceuticals is a $100M Series A biotechnology company advancing Positive Functional Modulators (PFMs), a novel class of oral, small molecules that restore and enhance membrane protein function to address the underlying cause of serious diseases. Rectifys PFMs have the potential to modulate the activity of wild-type and mutated membrane proteins, a historically difficult challenge for small molecule approaches. The Companys breakthrough product platform enables efficient and rapid discovery of first- and best-in-class small molecule therapies with the potential to address membrane protein dysfunction for treatment of rare and common diseases, including liver, cardio-renal-metabolic, and neurodegenerative diseases.

We are looking for a talented and motivated scientist with assay development and cell biology experience to join our passionate and collaborative team to help drive our internal drug discovery programs. In this lab-based position you will be responsible for the design, development, and deployment of cell-based and biochemical assays to generate decision making data in support of our PFM drug discovery pipeline and platform. Your work will directly influence the direction and success of our research portfolio. You will be deeply involved in a diverse range of technical projects including the development of fit-for-purpose in vitro assays for screening of small molecules, proof of mechanism studies, and in vitro translational model development. The ideal candidate will be a collaborative, driven, innovative and talented biologist familiar with the development, optimization, validation, and implementation of in vitro assays in a drug discovery setting. You should be team-oriented, technically adept, and excited to pick up new techniques and discover new biology.

The successful candidate will be a key member of the Rectify Research Team. As one of the early employees in a rapidly growing company, you will have ample opportunity for development and growth and will be a key contributor to shaping the Companys future. You will deliver and experience real value. This role offers a unique chance to stretch your talent and grow your potential.

Job Responsibilities :

  • Lead from the bench and be responsible for developing in vitro fit-for-purpose assays to support Rectifys portfolio as well as our PFM platform.
  • Apply state-of-the-art cell biology and biochemistry techniques for imaging-based analyses and protein quantitation.
  • Work closely with the chemistry team and the rest of the biology team to perform compound screening activities internally or through management of our external partner CROs to provide decision enabling data.
  • Perform mammalian cell culture to execute cell-based assays and / or protein expression quantitation.
  • Work effectively in a highly collaborative and efficiently working team environment.

Qualifications :

  • PhD in cell biology / biochemistry / biotechnology with 0-5 years or Masters with 6-10 of industry and / or academic experience.
  • Strong preference given to candidates with expertise in renal cellular systems and experience in drug discovery for renal indications.
  • Experience with mammalian primary cell culture is a must. Working knowledge of iPSC-derived cell systems is a plus.
  • Hands-on CRISPR gene-editing experience, electrophysiology and / or calcium imaging familiarity are preferred.
  • Ability to successfully participate in a highly creative, fast-paced, and enthusiastic start-up environment with people who are motivated to succeed together as a team.
  • Ability to work on multiple tasks / projects, manage timelines, and communicate effectively across an organization.
  • Additional Information

    This role is an onsite, lab-based position and 5 days a week in the office, on average, is required.

    We believe diverse backgrounds lead to innovative thinking. Rectify is committed to making our organization an inclusive place for all individuals regardless of race, religion, national origin, age, sex and gender identity, sexual orientation, pregnancy status, familial status, disability status, veteran status, genetic information or any other protected class. We are also committed to providing reasonable accommodations to qualified individuals with disabilities. If you are selected to interview, to request an accommodation either as part of the interview process or during your potential employment with Rectify, please let a member of our HR team know.

    If you feel energized by what you read here, but arent sure you meet every requirement, please consider applying! Above all, were looking for the right person with skills and talent to grow the company together all while enriching your professional experience.

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