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Engineering Co-op, Downstream Process Development

Sarepta Therapeutics
Burlington, MA Full Time
POSTED ON 3/29/2025
AVAILABLE BEFORE 5/28/2025

Why Sarepta? Why Now?

The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold leadership positions in Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophies (LGMDs), and we currently have more than 40 programs in various stages of development in gene therapy, RNA and gene editing. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.

We're looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.

What Sarepta Offers

At Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity.

The Importance of the Role

The co-op in gene therapy downstream process development will give insight into the manufacturing process for complex viral vectors along with hands-on production experience using bioprocessing techniques - including depth filtration, tangential flow filtration, and liquid chromatography. The co-op student will not only have the opportunity to interact with the downstream team, but also the upstream, analytical development, and formulation teams to learn how drug products are developed safely, cost-effectively, and efficiently from lab scale (10L) to commercial scale (>1000L).

In addition, co-op students will be exposed to leading-edge development approaches and technologies used to overcome major challenges in the bioprocessing sector, such as design of experiments, process intensification, and high-throughput automation. Timing permitting, the co-op will also experience what goes into tech transfer at the early-stage development site. The highly collaborative environment of Sarepta Therapeutics will expose the co-op to the nature of the job of multiple teams, departments, and leadership in getting therapeutic molecules from research to the clinic.

The Opportunity to Make a Difference

This application is for a 6-month co-op program that will start on July 7th, 2025, and conclude on December 19th, 2025. This is a full-time, 40 hours a week, co-op program.

  • Assist downstream scientists in the design, preparation, and execution of process development experiments.

  • Work independently on a research project aimed at optimizing a select unit operation within the downstream process for AAV manufacturing.

  • Participate in weekly process development meetings.

  • Refinement of laboratory skills via introduction to new experimental techniques, exposure to current challenges in bioprocess research, and perspectives on the practical aspects of drug development.

More about You

  • Undergraduate (junior or senior) or graduate student majoring in a science-oriented field, preferably (but not limited to) chemical engineering, bioengineering, biomedical engineering.

  • One year of laboratory research experience or equivalent is preferred.

  • Experience with protein purification is preferred.

  • Experience with statistical software such as JMP or SIMCA is a plus.

  • Proficiency in Microsoft Office (Word, Excel, PowerPoint) is required.

  • This role is on-site and will require regular work in a laboratory setting.

What Now?

We're always looking for solution-oriented, critical thinkers.

So, if you're comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.

#LI-Onsite#LI-MC1

This position requires work on site at one of Sarepta's facilities in the United States.

The targeted salary range for this position is $22 - $34 per hour depending upon years of education completed and nature of role.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.

 

Salary : $22 - $34

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