What are the responsibilities and job description for the Scientist II, Upstream position at Solid Biosciences?
Position Summary
Solid Biosciences is seeking a motivated scientist to join our Upstream Process Development (USPD) team. The USPD team is responsible for the development and optimization of the upstream manufacturing processes for our viral vector portfolio. For the candidate to be successful, collaboration that ranges across departments will be essential. Not only will the candidate collaborate with downstream process development and analytical development to assess/enable high product quality, they will also collaborate with R&D. This integration catalyzes new technology incorporation and the next generation of upstream processes. Finally, the candidate will be expected to enable successful implementation of the process at a contract manufacturing organization.
Creation of a cell culture based AAV production process will be the focus of this role, as well as USPD at large. That said, given the high time investment and relatively low throughput of cell culture based experimentation, we seek a candidate with modeling experience. These models can then be leveraged to create process analytical technologies, optimized upstream processes, and increase overall process understanding. Appreciating and discerning how a given decision within the upstream process impacts product quality and yield is a fundamental need. Knowledge and appreciation of transient transfections of mammalian cell culture will be key to creating useful models.
Finally, this position will support the evaluation, testing, and implementation of new upstream technologies. A successful candidate must be comfortable working in a lab setting, accomplishing tasks both independently, as well as within a collaborative team environment. Excellent communication and organizational skills are a must.
Key Duties & Accountabilities
Some travel may be required
Solid Biosciences is seeking a motivated scientist to join our Upstream Process Development (USPD) team. The USPD team is responsible for the development and optimization of the upstream manufacturing processes for our viral vector portfolio. For the candidate to be successful, collaboration that ranges across departments will be essential. Not only will the candidate collaborate with downstream process development and analytical development to assess/enable high product quality, they will also collaborate with R&D. This integration catalyzes new technology incorporation and the next generation of upstream processes. Finally, the candidate will be expected to enable successful implementation of the process at a contract manufacturing organization.
Creation of a cell culture based AAV production process will be the focus of this role, as well as USPD at large. That said, given the high time investment and relatively low throughput of cell culture based experimentation, we seek a candidate with modeling experience. These models can then be leveraged to create process analytical technologies, optimized upstream processes, and increase overall process understanding. Appreciating and discerning how a given decision within the upstream process impacts product quality and yield is a fundamental need. Knowledge and appreciation of transient transfections of mammalian cell culture will be key to creating useful models.
Finally, this position will support the evaluation, testing, and implementation of new upstream technologies. A successful candidate must be comfortable working in a lab setting, accomplishing tasks both independently, as well as within a collaborative team environment. Excellent communication and organizational skills are a must.
Key Duties & Accountabilities
- The creation and independent execution of sound experimental designs.
- Statistical analysis of experimental results.
- Creation of empirical (or theoretical) models to explain and predict process performance.
- Evaluation, testing, and implementation of new upstream technologies.
- Working effectively in a team environment.
- Support experimental set-up and coordination with other PD scientists (i.e. bioreactor set up, probe calibration/maintenance, cell culture passaging).
- Inputting results into electronic notebooks/data management systems.
- Routine sample analysis using various laboratory analytical tools.
- Excellent communication, technical, and organizational skills are required
- Must be a team player prepared to work within a collaborative team-based culture
- Willingness to work on weekend on occasion (as dictated by active cell culture)
- Doctoral degree in Science, Engineering, or relevant discipline. 2-5 years of industry experience.
- Master's degree in Science, Engineering, or relevant discipline. 5-8 years of industry experience.
- Experience with empirical (such as machine learning) or theoretical modeling.
- Flexibility to grow and adapt as the business evolves.
- Experience with Mammalian cell culture
- Experience with bioreactors
- Experience working in an upstream process development lab.
- Experience with transient transfections.
- Experience with AAV.
- Experience with automation.
Some travel may be required
Salary : $122,000 - $151,000
