What are the responsibilities and job description for the Principal Scientist, Assay Development position at Spear Bio?
About Spear Bio :
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Spear Bio, founded in 2021, is a well-funded and rapidly growing start-up headquartered in Woburn, Massachusetts. Our proprietary technology, Successive Proximity Extension Amplification Reaction (SPEAR), is a novel wash-free immunoassay platform, offering unprecedented sensitivity. We are dedicated to revolutionizing early disease diagnosis and monitoring by providing scalable, ultrasensitive solutions that enable accurate measurement of low abundant biomarkers, and empowering clinicians and researchers to improve patient outcomes and advance global health.
Principal Scientist :
The Principal Scientist will help lead one of Spear Bio’s Assay Development teams and contribute to the development and verification of our new range of ultrasensitive immunoassays. This role will have cross-functional responsibilities and work closely with the Platform and Product Development teams. The Principal Scientist will be expected to have a strong track record in immunoassay development for research and clinical applications and a deep understanding of protein biology.
Responsibilities :
- Lead a team of junior scientists in developing a portfolio of assays, and qualify and / or validate assays for research and clinical use.
- Be a subject matter expert in the field of protein biomarkers for neurodegeneration or immuno-oncology.
- Design and develop ELISA based assays for ultrasensitive detection of analytes including antibody selection, conjugation of reagents and chemistries, sample preparation and handling, data analysis methodologies.
- Design and perform experiments to demonstrate feasibility and characterize performance and robustness (dynamic range, limit of detection, spike and recovery, precision, accuracy, and assay linearity) of ELISA based assays.
- Contribute to scientific literature and internal reports, documents, and communications including the writing and / or creation of abstracts, peer-reviewed journal articles, poster presentations, and marketing materials, and represent Spear Bio at conferences.
- Maintain familiarity with current technology and related literature and conduct project related information searches (some searches may be extensive).
- Apply strong analytical and problem-solving skills, with demonstrated knowledge of statistical methodologies including DoE.
- Experience working within a cGMP / GLP and ISO regulated quality system.
- Work independently and have a strong understanding of the theory and biology behind the application and products.
- Possess strong presentation and interpersonal skills with the ability to establish collaborative working relationships and become a key contributor within the assay development, platform, and product teams.
- Excellent project management skills with the ability to manage and organize work around multiple and changing priorities.
Requirements :
We offer competitive compensation, with meaningful stock ownership, strong benefits, and a great work environment. This is an opportunity to enter a high-growth startup company at an early stage. We are recruiting candidates who have demonstrated leadership and excellence throughout their careers and are excited by contributing to building an industry-leading company.
Spear Bio Inc. provides equal opportunity in employment to all persons. No person shall be denied equal access because of race, creed, color, religion, national origin, sex, sexual orientation, gender identity, age, or physical / mental disability.
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