Principal Scientist, Computational Chemistry Pharmacy (Apply in minutes)

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• Job Description
• Job Posting DescriptionAt Takeda, we are a forward-looking, world-class R&D; organization thatunlocks innovation and delivers transformative therapies to patients. Byfocusing R&D; efforts on three therapeutic areas and other targetedinvestments, we push the boundaries of what is possible to bring life-changingtherapies to patients worldwide.
• Objective Purpose :
• As a Computational Chemistry Leader, you will work as part of a multi-disciplinary team of Medicinal Chemists, Computational Chemists, Data Scientist, Structural Biologists, Pharmacologists and Biologists to provide Computational expertise to advance drug discovery projects
• Contribute to drug discovery efforts across various modalities including small molecules, bifunctional degraders, peptides, RNAoligonucleotides, and biologics
• Implement and execute innovative computational methodologies and tools such as AI approaches to support drug discovery efforts
• Accountabilities :
• Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment
• Identify, develop, validate, and implement innovative computational approaches that improve research productivity and success
• Provide crucial technical knowledge and input to project teams to drive decision-making in drug discovery projects
• Build and develop a strong team of Computational Chemists to high productivity levels
• Demonstrate leadership and enterprise thinking in managing multi-disciplinary team
• DIMENSIONS AND ASPECTS :
• Expertise in a variety of computational tools and methodologies including docking, virtual screening, molecular dynamics, free energy perturbation, homology modeling, quantum mechanics, pharmacophore elucidation, data mining, machine learning, cheminformatics, clustering, similarity & diversity analysis
• Significant Industry experience contributing as Computational Chemist on drug discovery projects
• Strong Impact in progressing Discovery Projects from Hits to Clinical Leads
• Extensive knowledge & experience in using a variety of tools for Hit ID
• Provide project teams with computational strategies to inform, influence, and prioritize compound designs for potencyselectivity and improve ADMETox endpoints
• Ability to effectively integrate emerging generative chemistry methods and other modern machine learning and artificial intelligence (AI) applications in small molecule drug discovery
• Proficiency with state-of-the-art Computational Chemistry software
• Network with renowned researchers in computational chemistryAI
• EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS :
• PhD degree in a relevant scientific discipline
• 6 years of Industry (pharmabiotech) drug discovery experience required
• Takeda Compensation and Benefits Summary
• We understand compensation is an important factor as you consider the nextstep in your career. We are committed to equitable pay for all employees, andwe strive to be more transparent with our pay practices.
• For Location :
• Boston, MA
• U.S. Base Salary Range :
• 149,100.00 - 234,300.00The estimated salary range reflects an anticipated range for this position.The actual base salary offered may depend on a variety of factors, includingthe qualifications of the individual applicant for the position, years ofrelevant experience, specific and unique skills, level of education attained,certifications or other professional licenses held, and the location in whichthe applicant lives andor from which they will be performing the job. Theactual base salary offered will be in accordance with state or local minimumwage requirements for the job location.U.S. based employees may be eligible for short-term and or long-termincentives. U.S. based employees may be eligible to participate in medical,dental, vision insurance, a 401(k) plan and company match, short-term andlong-term disability coverage, basic life insurance, a tuition reimbursementprogram, paid volunteer time off, company holidays, and well-being benefits,among others. U.S. based employees are also eligible to receive, per calendaryear, up to 80 hours of sick time, and new hires are eligible to accrue up to120 hours of paid vacation.
• EEO Statement_
• Takeda is proud in its commitment to creating a diverse workforce andproviding equal employment opportunities to all employees and applicants foremployment without regard to race, color, religion, sex, sexual orientation,gender identity, gender expression, parental status, national origin, age,disability, citizenship status, genetic information or characteristics,marital status, status as a Vietnam era veteran, special disabled veteran, orother protected veteran in accordance with applicable federal, state and locallaws, and any other characteristic protected by law._##
• Locations
• Boston, MA##
• Worker Type
• Employee##
• Worker Sub-Type
• Regular##
• Time Type
• Full time
• Job Exempt