Research Associate II

Details for the position are as follows:

• Location: South San Francisco, CA
• Rate: $$30.51-54.76 an hour depending on experience.
• 12-month contract to start with the possibility of extension or conversion depending on performance.

Job Description:

• The mission of the Investigative Toxicology group is to elucidate the mechanisms underlying toxicities that are observed non-clinically and / or in clinical trials through hypothesis driven research.
• This process involves closely collaborating with scientists across the organization to support the overall safety assessment for our Client therapeutics spanning drug discovery through clinical development and marketing.
• The group provides fit-for-purpose wet lab-based investigation to address target safety assessment, lead optimization and issue mitigation by employing state-of-the-science in vitro and ex vivo approaches.
• As such, we are constantly establishing new platforms and technologies to support a dynamic portfolio, Client modalities and emerging therapeutic area needs. We are looking for a highly motivated candidate to work in collaboration with other researchers in the Investigative Toxicology lab.
• This laboratory-based role involves performing, qualifying and implementing biological assays and technologies to support the Investigative Toxicology group.
• The candidate must have experience in cell culture and will be responsible for: culturing and expanding primary cells and cell lines for in vitro screenings, treating and performing assays to assess cytotoxicity and metabolic changes of cells, capturing cell culture images using confocal and high content imaging.
• This individual will be working with cells from a broad range of tissues (e.g., liver, lung, biliary, ocular) and is expected to make detailed observations related to experiments, perform, analyze data and interpret results.
• They will contribute with scientific insights and also work on projects related to peer review publications.
• The individual will also participate in the development of Client in vitro platforms / approaches to support toxicity testing for our drug discovery programs.
• This is an ideal position for a researcher who is enthusiastic about learning and contributing to projects with a broad range of techniques.

Required Skills:

• Bachelors (BS / BA) in pharmacology, pharmaceutical science, biology, bioengineering, chemistry, physiology, or related discipline is required; Masters (MS) degree is desirable, but not required.
• 1-3 years of laboratory experience with hypothesis-driven research.
• Ability to analyze, integrate, and present data in a presentation is required.
• Experience with immortalized and / or primary cell culture is required
• Experience with cell viability assessment, ELISAs, gene expression analysis, high content screening, confocal microscopy, and flow cytometry is highly desired.
• Experience with complex in vitro model systems is highly desired.