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Research Associate in Supramolecular Chemistry

The University of Manchester
Oxford, CT Temporary
POSTED ON 1/17/2025
AVAILABLE BEFORE 4/14/2025

Development of Novel Metal-Organic Cages for Applications in Sensing and Catalysis’

A position is available for a Postdoctoral Research Associate with experience in organic synthesis and supramolecular chemistry. The position will commence on, or as soon as possible after, the 10th March 2025. The successful candidate will support established projects working towards the development of catalytic metal-organic cages, as well as cages developed for binding and recognition of biological substrates. The candidate is expected to be highly independent and will be tasked with the day-to-day management of the Riddell research group, as well as providing supervision and guidance to PhD students currently working in the lab. This is an excellent opportunity for a highly ambitious researcher looking for the opportunity to demonstrate their potential to run an academic research group.

Metal-organic cages have, to date, found diverse applications ranging from gas binding to chemical separation and drug delivery. Many limitations persist for cages reported in the literature however, including the limited internal cavity dimensions, cage solubility and stability. Additionally, the lack of utilisation of the metal ions beyond their structural capacity remains an untapped opportunity for this class of complexes. In recent years the Riddell group has focussed on the development of (i) water-soluble capsules with cavities larger than those typically found in the literature, (ii) the formation of lower symmetry cages with asymmetric binding pockets and (iii) the application of these novel constructs, particularly to biological problems and as novel catalysts. This appointment will involve supporting and developing organic and self-assembly synthesis strategies to diversify metal-organic cages enabling further expansion of their application scope. Where novel cages are identified a range of characterisation techniques will be employed including NMR spectroscopy (1D, 2D and heteronuclear), mass spectrometry and single crystal X-ray diffraction. Experience in each of these techniques with regard to supramolecular complex characterisation is highly desirable. If time allows development of the complexes towards targeted applications may also be carried out, either in the lab or working together with appropriately chosen collaborators.

Applicants should have or expect to attain a PhD or equivalent in Chemistry and have submitted their thesis prior to taking up the position. In particular, we seek applications from researchers experienced in organic synthesis and metal-organic supramolecular self-assembly and characterisation. The candidate should also have a proven record of supporting junior researchers, working in a collaborative manner and excellent communication and organisational skills.

The Department of Chemistry is strongly committed to promoting equality and diversity, including the Athena SWAN Charter for gender equality in higher education. The School holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff to achieve a good work-life balance. We particularly welcome applications from women for this post. Appointment will always be made on merit.

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