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PK / PD Scientist

The University of Texas MD Anderson Cancer Center
San Diego, CA Full Time
POSTED ON 1/17/2025
AVAILABLE BEFORE 4/16/2025

Job Title : PK / PD Scientist

The experience expected from applicants, as well as additional skills and qualifications needed for this job are listed below.

Job Number : 88522

Location : San Diego, US

Job Description :

We are seeking a dedicated and highly skilled Scientist for our Preclinical Team. The successful candidate will support the progression of our therapeutic programs by conducting and optimizing in vivo research activities and executing preclinical studies. This role demands a solid understanding of PK / PD analysis, in vivo research methodologies, and the ability to perform in complex operations.

Responsibilities

  • Work with the Associate Director, providing in vivo pharmacology expertise.
  • Plan, execute and manage in vivo studies, including protocol development, dosing and tissue collection, study monitoring, bio sample management, tissue processing, and relevant data analysis.
  • Proficient in administering substances by intravenous (IV), intraperitoneal (IP), subcutaneous (SC), intramuscular (IM), and intertumoral (IT) injections.
  • Execute cell-based assays and experiments of tissues from in vivo studies, perform analyses, and report results.
  • Conduct survival surgeries to establish various rodent models using aseptic techniques.
  • Develop, characterize, and implement new animal models to improve the effectiveness of in vivo pharmacology studies.
  • Maintain detailed documentation of all studies in a lab notebook to ensure data integrity and traceability.
  • Optimize and implement best practices for in vivo research methodologies, including animal model selection, dosing strategies, sample collection, and data collection techniques.
  • Ensure compliance with regulatory guidelines and ethical standards in the conduct of in vivo studies.
  • Evaluate and implement new technologies and platforms to enhance the efficiency and quality of in vivo studies.
  • Perform and analyze preclinical imaging studies (IVIS).
  • Contribute to a team culture that promotes continuous improvement, ownership, professional growth, and inclusion.

Required Skills

  • DVM or Ph.D. with expertise in nonclinical operations in a drug discovery and development setting.
  • Broad and extensive expertise with all aspects of in vivo rodent research (various dosing routes, anesthesia, surgical procedures, necropsy, tissue processing, etc.).
  • 3Rs-centered, welfare-oriented approach to animal-based research.
  • Strong communication skills, essential for effective collaboration with cross-functional teams and CROs used for outsourced studies.
  • Exceptional organizational and attention to detail skills, with the capacity to work autonomously as well as in a team setting.
  • Ability to troubleshoot and effectively solve problems in a timely and efficient manner, demonstrating resourcefulness and a high level of analytical thinking.
  • Hands-on experience with cell biology techniques (RNA / DNA extraction, PCR, Western Blot, ELISA, small molecule / biologics interventional assays).
  • Preferred Qualifications

  • Experience working across diverse therapeutic modalities, including small molecules, biotherapeutics, nucleic acid therapeutics, and gene therapy.
  • Experience analyzing age-related diseases / deficits in animal models, including inflammation, metabolic disorders, neurodegeneration, muscle atrophy, bone loss, and / or joint deficits.
  • Experience with metabolic chambers, behavioral assay, and analysis.
  • Application Deadline : 2024-12-16

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