What are the responsibilities and job description for the Scientist/Sr. Scientist – Quantitative Mechanistic Biology/Pharmacology position at Third Rock Ventures?
Scientist / Sr. Scientist – Quantitative Mechanistic Biology / Pharmacology
A well-funded and highly innovative start up from Third Rock Ventures is emerging out of stealth with a syndicate of marquee investors and is seeking a quantitative biologist / pharmacologist to become an integral part of the Quantitative Sciences group. The successful candidate will report to the VP of Quantitative Sciences and will work closely with the Preclinical Biology and Clinical teams to apply mechanistic modeling, simulation, and other quantitative analysis tools to drive drug discovery and development decisions. The ideal candidate will have a strong theoretical quantitative background, excellent practical coding skills, and experience and broad interest in a relevant biological or biomedical field.
Key Responsibilities :
- Build, develop, and / or use mechanistic models of drug pharmacokinetics and pharmacodynamics, disease processes, and clinical trial simulations. These models will be applied at various stages of drug development from early feasibility through lead selection and clinical trial design.
- Oversee the work of external partners in developing, evaluating, and optimizing some of these models.
- Perform secondary analyses of model outputs, create insightful visualizations and summaries, and communicate results to the broader organization.
- Work closely with in vivo pharmacology team to support quantitative study design and analysis aimed at various biological and pharmacological questions.Together with clinical pharmacology team, analyze data in a quantitative systems pharmacology modeling framework to infer key parameters and inform clinical decision-making.
Candidate Requirements :
