Scientist

Job Title: Scientist, Preformulation

📍 Location: Cambridge, MA

📄 Contract Length: 6 months

Job Summary:

We are seeking an exceptional candidate to contribute to preformulation research in a small, fast-paced, and highly collaborative team. This contract position is within the Formulation Sciences group of Technical Operations, supporting pre-clinical development.

The candidate will work full-time onsite and be responsible for executing laboratory activities related to the transition of novel small molecule compounds from Discovery into Development. The role directly supports pre-clinical and clinical programs.

An ideal candidate will have a strong foundation in analytical techniques such as UPLC/HPLC (Empower proficiency) and an understanding of early drug development processes and experiments. Experience in preformulation development and physicochemical characterization is highly desirable but not required.

Ideal Experience: 0-3 years in pharmaceutical sciences (preformulation, analytical, or formulation development).

Key Responsibilities:

✔️ Prepare buffers and common lab solutions

✔️ Execute analytical experiments using XRPD, DSC, TGA, DVS, optical microscopy, and UPLC/HPLC (Empower)

✔️ Screen excipients/formulation vehicles for solubility and stability to optimize preclinical formulations for non-GLP and GLP preclinical studies

✔️ Perform drug substance and formulation stability studies to ensure optimal formulation design

✔️ Coordinate vehicle/formulation preparations for in vivo studies

✔️ Maintain an accurate, timely, and compliant laboratory notebook

Qualifications:

🎓 Education: BS degree in chemistry, analytical chemistry, pharmaceutics, chemical engineering, or material sciences

🧪 Experience in the Discovery and Development interface (desirable but not required)

⚗️ Hands-on experience with common excipients and volumetric glassware

🖥️ Proficiency with UPLC/HPLC and Empower Software

🔬 Knowledge of and interest in small molecule and pre-clinical formulation development

Capabilities & Skills:

✅ Ability to prioritize and manage multiple tasks

✅ Self-motivated with a willingness to learn and seek assistance when needed

✅ Comfortable in a results-driven, highly accountable environment

✅ Strong team player and collaborator, with effective communication skills

Preferred Technical Skills:

🔹 Laboratory Equipment & Techniques

🔹 Pharmaceutical Formulation

🔹 Thermal Analysis (DSC, TGA, DVS)

🔹 Analytical Chemistry

🔹 Waters HPLC & Empower Software

🔹 Polarized Light Microscopy

🔹 Preclinical Drug Development

All applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, or protected veteran status.

👉 Interested? Apply today!