What are the responsibilities and job description for the Postdoctoral Scholar Position in RNA Modifications, Metabolism, and Aging position at University of Chicago?
The De Jesus Laboratory in the Department of Medicine, Section of Genetic Medicine, at the University of Chicago is seeking a highly-motivated postdoctoral scholar to join our team. Our research focuses on m6A mRNA methylation and its impact on metabolism and aging, with a particular emphasis on how this RNA modification regulates the function of various metabolic organs.
Our prior work has revealed critical roles for m6A in metabolic regulation and cellular processes across different tissues: a) pancreatic islet biology (Nature Metabolism, PMID: 31867565; Nature Cell Biology, PMID: 31867565; EMBO Journal, PMID: 39322760), b) brown adipose tissue (Cell Metabolism, PMID: 39322760), and c) white adipose tissue (Nature Communications, PMID: 39788955). This body of work underscores the diverse and critical roles of m6A RNA methylation in regulating metabolic homeostasis, making it a promising area of research to address pressing questions in aging and disease.
The lab is located in the state-of-the-art Knapp Center for Biomedical Discovery (KCBD), which houses the Kovler Diabetes Center and provides a highly collaborative environment for research in genetics, diabetes, and related fields.
Key Responsibilities:
- Conduct cutting-edge research on RNA modifications, particularly the roles of m6A methylation and its adaptor proteins.
- Design and execute experiments using advanced molecular biology, transcriptomics, epitranscriptomics, and cell-based assays.
- Utilize mouse models to investigate the physiological relevance of m6A pathways in metabolism and DNA damage/senescence.
- Analyze omics datasets, including transcriptomics and epitranscriptomics, to uncover novel regulatory mechanisms.
- Collaborate with a multidisciplinary team of researchers and contribute to ongoing projects in the lab.
- Prepare and publish high-impact manuscripts and present findings at national and international conferences.
Qualifications:
- A PhD in basic biology, genetics, biochemistry, or a related field (must have graduated within the past year or be expected to graduate soon);
- Expertise in RNA biology, epigenetics, metabolism, or aging is highly desirable.
- Experience working with animal models (e.g. mice);
- Proficiency in techniques such as qPCR, WB, immunoprecipitation, immunofluorescence, mRNA-seq, is fundamental;
- Knowledge of bioinformatics tools and approaches for omics data analysis is advantageous.
- Strong problem-solving skills, attention to detail, and ability to work independently and as part of a team.
Why Join Us?
The De Jesus Laboratory offers an exciting and collaborative environment to pursue innovative research questions at the intersection of RNA biology, metabolism, and aging. Our lab is committed to providing mentorship, training, and resources to support your career development.
The University of Chicago is one of the top universities in the world, renowned for its academic rigor and groundbreaking research. Located in the historic Hyde Park neighborhood, the area boasts a rich cultural and intellectual environment. Hyde Park offers a relatively affordable cost of living compared to other major cities, making it an ideal place to live and work.
The position is fully-funded; the appointee will receive a salary based on qualifications and experience, in compliance with NIH levels. The position also includes benefits eligibility via The University of Chicago Postdoctoral Researcher Benefit Program (PRBP), provided by Gallagher: https://clients.garnett-powers.com/pd/uchicago/. The University of Chicago provides access to state-of-the-art facilities and fosters a vibrant research community.
Application Details:
To apply, please send the following as a single PDF to: dariofdejesus@uchicago.edu
- A one-page cover letter describing your research interests, career goals, and fit for this position.
- A detailed CV, including a list of publications.
- Contact information for two professional references.
Applications will be reviewed on a rolling basis until the position is filled. The anticipated start date is May 2025, but this is flexible.
We value diversity and encourage individuals from underrepresented groups to apply.
