Principal Engineer, Process Chemistry

The Company

Verve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company’s initial three programs – VERVE-101, VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2024, Verve was named a Top Place to Work by The Boston Globe for the fourth consecutive year. Verve is headquartered in Boston, Massachusetts.

The Position

As Principal Engineer in the Technology Transfer and Process Engineering group you will have a highly visible and integral role in process engineering, scale-up, and manufacturing of Verve’s novel lipid excipients for use in novel LNPs for gene editing applications. This position will drive technical readiness for manufacturing scale-up and production at contract manufacturing sites. The position will also take an integral role in process characterization efforts and collaborate with the broader Tech Ops organization to understand process and product impurities.

Job Responsibilities

• Support ongoing manufacturing from readiness through release, including troubleshooting in close cooperation with CMOs and internal stakeholders, review of executed batch records, and process trending. Some travel to manufacturing sites will be required.
• Life cycle management of the manufacturing process, including authoring of change control, deviation investigations, and implementation of process improvements.
• Collaborate with cross-functional groups to expand understanding of process and product impurities in novel excipients and LNP-based drug product.
• Lead technical efforts to establish additional lipid excipient vendors.
• Write technical reports and contribute to global regulatory filings to support clinical development of Verve’s products.
• Collaborate with cross-functional teams including R&D Chemistry, Process Development, Preclinical Toxicology, Analytical Development, Quality Control, Quality Affairs, Regulatory Affairs, and External Manufacturing.
• Contribute to a team that is focused on science-based understanding of lipids and LNP manufacturing for global GMP clinical supply.
• Other duties as required.
  
  

Qualifications

• Ph.D. in organic chemistry or related scientific field and 6 years process engineering experience, M.S. with 8 years experience, or B.S. with 12 years experience. Organic chemistry and chemical engineering candidates are encouraged to apply.
• Industry experience in a biotechnology or pharmaceutical company required. Small molecule or lipid experience required. Preference for strong chromatography experience at large manufacturing scale.
• Strong gap assessment, relationship management, and organizational planning skills.
• Knowledge of GMP requirements for manufacturing (especially raw materials), equipment, and process.
• Collaborative and detail-oriented approach to work across multiple teams. Strong communication and risk-based decision-making skills.
• Attention to detail, critical analysis of data/reports, and troubleshooting abilities.
• Proven ability to achieve results as an individual contributor and drive technical solutions to complex problems in a collaborative environment.
• Domestic and international travel required (up to 10%).
  
  

Don’t check off every box in the requirements listed above? Please consider applying anyway. We want the best candidates for the job, and those candidates don’t always meet 100% of the qualifications listed. At Verve, we are dedicated to building diverse and inclusive teams who embody the values we share: grit, spirit, drive, and passion. We look forward to learning more about your unique background.

EEO Statement

Verve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.

Recruitment & Staffing Agencies

Verve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location; Verve Therapeutics is not responsible for any fees related to unsolicited resumes.