Scientist/Scientist II, Molecular and Potency, Analytical CMC

The Company

Verve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company’s initial three programs – VERVE-101, VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2024, Verve was named a Top Place to Work by The Boston Globe for the fourth consecutive year. Verve is headquartered in Boston, Massachusetts.

The Position

Verve is seeking a Scientist or Scientist II within the Analytical CMC team, to interface with Process Development, Internal and External Quality Control in developing, implementing, and transferring molecular and cell biology-based methods to characterize mRNA, gRNA and LNP-encapsulated gRNA and mRNA. This individual will be interfacing with a cross-functional team to design, develop and support phase- appropriate qualification of analytical methods to enable Verve’s growing gene editing pipeline.

Job Responsibilities

• Develop, optimize, and execute analytical methods intended for a variety of purposes, including release and stability testing, product characterization, high throughput analysis, and characterization of complex raw materials.
• Improve existing cell-based assays with a focus on improving robustness, reproducibility, and accuracy.
• Collaborate across multiple cross-functional teams to perform experiments and summarize work in presentations and technical reports.
• Author, review, and approve protocols, SOPs, technical reports, and sections of regulatory submissions.
• Perform laboratory experiments while providing leadership and mentorship to junior scientific team members.
• Continuously monitor the literature to identify gaps in existing methods and mobilize Verve resources to complete gap analysis.
• Act as an advisor to provide routine guidance to both the internal team and contract testing laboratories (CTL) to resolve technical problems.
• Review analytical data and provide feedback to both external and internal teams. Assist in continuous improvement activities.
• Develop and apply molecular biological methods, immunoassays, and other state of the art technologies to analyze and characterize cell and gene products.
• Analyze, track, and trend data to monitor analytical assays and ensure consistency in assay performance.
• Maintain detailed documentation of experiments in ELN system Experience automating lab procedures is highly desirable.
• Other duties as assigned.
  
  

Qualifications

• Hands on experience developing and troubleshooting analytical methods applied to complex and heterogenous systems.
• Deep understanding of cell-based assay development and validation, preferably with lipid nanoparticles.
• Experience in assay development, qualification, validation, and implementation to support target candidate validation from Non-GxP to GMP environments.
• A collaborative and proactive mindset, taking initiative to drive tasks to completion.
• Demonstrated experience in supervising and developing junior scientific team members.
• Scientist requirements:
• M.S. in Biochemistry, Molecular Biology and/or related life sciences field with strong scientific background and 4-7 years’ relevant experience or PhD and 0-2 years relevant experience.
• Scientist II requirements
• M.S. in Biochemistry, Molecular Biology and/or related life sciences field with strong scientific background and 7 years’ relevant experience or PhD and 2 years relevant experience.
  

Don’t check off every box in the requirements listed above? Please consider applying anyway. We want the best candidates for the job, and those candidates don’t always meet 100% of the qualifications listed. At Verve, we are dedicated to building diverse and inclusive teams who embody the values we share: grit, spirit, drive, and passion. We look forward to learning more about your unique background.

EEO Statement

Verve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.

Recruitment & Staffing Agencies

Verve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location; Verve Therapeutics is not responsible for any fees related to unsolicited resumes.