Scientist/Senior Scientist/Principla Scientist, RNA therapeutics

Primary Responsibilities

·       Targets evaluation, target indications and competitive landscape assessment for RNA-based therapeutics, including siRNA, ASO and related disciplines

·       Perform preclinical candidate screening and optimization via combined in vitro and in vivo assays, working withina cross-disciplinary group, including discovery chemistry, CMC and other relevant functions

·       Determine mechanism of action of drug targets; design and execute proof-of-concept studies to validate targets together with internal and/or external partners

·       Lead projects from inception to development candidate nomination

·       Prepare key preclinical, clinical and regulatory documents, and patent application

·       Effectively manage multiple programs and deliver quality result within sensitive timelines

·       Comply with appropriate SOPs; if needed, train associates to meet requirements; present research findings to project teams, governance bodies, or external meetings

·       Effectively communicate across all organizational levels

Qualifications

·       PhD in biology, pharmacology, or related discipline with 4 years of experience in pharmaceutical/biotech industry or academic settings. The level of position will be determined by previous experience and achievements. 

·       Experience in ASO/siRNA and/or gene/base editing is highly desired.

·       Extensive experience conducting preclinical POC studies in the context of liver, extrahepatic tissues, such as nervous system (CNS or PNS), muscle

·       Track record of independent research and creativity, as demonstrated by quality publications and/or patents

·       Knowledge and ability to develop biochemical and molecular biology assays for RNA and protein quantification 

·       CRO and remote management of global resources, ranging from costing, execution, and interpretation of results in a timely manner

·       Ability to work independently and collaboratively 

·       Outstanding organizational and time management skills and must be a self-starter with the ability to thrive in a multi-disciplinary, collaborative, fast-paced, and team-oriented environment.

·       Excellent verbal and written communication skills