We advance science so that we all have more time with the people we love. The Department of Translational Medicine leads biomarker discovery and development efforts for programs in Early Stage Research through Phase III clinical trials for the disease areas of Ophthalmology, Metabolism, Neuroscience, Immunology and Infectious Diseases (TM-OMNI). We use relevant pharmacodynamic biomarkers to evaluate target engagement and mechanism of action of candidate therapies as well as prognostic and predictive biomarkers to guide patient selection and personalized healthcare strategies. Biomarker scientists within our department are responsible for developing biomarker strategies, designing and implementing biomarker assays, and interpreting biomarker results. Additionally, we conduct foundational clinical translational research to study the molecular and cellular pathways driving disease to generate novel target and biomarker approaches. The Opportunity: As a valuable member on the Translational Medicine Cardiovascular and Metabolism Diseases team you will be: Partnering closely with Research to lead preclinical biomarker discovery & development efforts to support research programs. Leading early and late stage clinical development decision-enabling biomarker strategies, integrate biomarker activities in clinical trials, generate biomarker data, and lead the analysis, interpretation and presentation of results. Partnering closely with global development teams to address key questions during late stage clinical development, including product differentiation, indication expansion, and patient response. Participating in or initiating external collaborations related to understanding disease pathogenesis and patient heterogeneity. Serving as the biomarker lead on cross-functional project teams and internal review committees. Collaborating closely with internal partners, including Research, Bioanalytical Sciences, Clinical Sciences, Preclinical and Clinical Pharmacology, Biostatistics, Regulatory, and Bioinformatics, as well as with external partners. Writing biomarker sections of clinical and non-clinical protocols, reports, and regulatory filings, publishing results in high quality journals, and presenting at external conferences. Who you are: We are looking for an individual who would be passionate about using their understanding of disease biology to make impactful contributions to clinical drug development. Success in these responsibilities will require: PhD, MD, or MD/PhD in Endocrinology, Cell Biology, Physiology, or related fields with 6 years post-doctoral, fellowship or industry experience and prior experience with translational research and/or clinical trials for cardiovascular and metabolic diseases (e.g. obesity, MASH, diabetes). Experience in, and deep technical understanding of, preclinical and clinical sample collection/processing and cellular/molecular lab techniques such as cell culture, primary cell isolation from tissues, immunostaining, molecular biology, ELISA, western blot, flow cytometry, genomic sequencing, qRT-PCR, and/or transcriptomics is required. Must demonstrate a high level of independence with ability to develop hypotheses, direct lab scientists, develop analysis plans, interpret and present results. Preferred candidates will have prior biostatistics or bioinformatics experience (omics, pathway, network analysis, etc.) with programming skills in Python or R. Strong written and verbal communication skills, as evidenced by publications, external presentations, and drug development reports, are required, along with extensive experience in leading R&D teams and fostering internal collaborations and partnerships with academic universities. Willingness to collaborate across time zones, including our Swiss site, is a must. Relocation benefits are available for this job posting. The expected salary range for this position based on the primary location of South San Francisco, California is $176,600- $328,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. Who We Are Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work. The next step is yours. To apply today, click on the "Apply for this job" button. Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page. If you are in need of an accommodation due to a disability to assist with submitting your application or at any point during the hiring process, please email US.accommodation@roche.com.