Senior Scientist, Antibody Drug Conjugates (ADCs) and Radioconjugates (RCs) Bioconjugation

Gaithersburg, MD

Are you passionate about advancing the frontiers of Oncology? We are seeking a dynamic and proficient Senior Scientist in Bioconjugation to join our Oncology R&D team. This role offers an exciting opportunity to spearhead and contribute to multifaceted drug development endeavors, taking our leading Oncology pipeline to the next level.

Accountabilities:

As a Senior Scientist, you will execute conjugation, purification, and characterization of Antibody Drug Conjugates (ADCs) and Radioconjugates (RCs). You will innovate and optimize novel conjugation techniques to enhance ADC/RC properties and coordinate and streamline conjugation workflows within a collaborative team environment. Leading and overseeing laboratory operations, including equipment maintenance and adherence to safety protocols, will also be part of your responsibilities.

Essential Skills/Experience:

• PhD in Organic Chemistry, Chemical Biology, Biochemistry, or related field with 0-3 yrs relevant experience OR Master's degree in Organic Chemistry, Chemical Biology, Biochemistry, or related field with at least 8 years of relevant experience.
• Extensive hands-on expertise in designing and generating antibody drug conjugates.
• Proficiency in analytical characterization techniques such as Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid Chromatography–Mass Spectrometry (LC-MS), Ion-Exchange (IEX), and Reversed Phase (RP)-HPLC.
• Hands-on experience in protein purification using HIC, IEX, SEC, and affinity chromatography, preferably with GE AKTA FPLC.
• Consistent record of working autonomously, adeptly planning and organizing tasks, and prioritizing activities to meet project deadlines.
• Demonstrated skill in protocol optimization and troubleshooting with a problem-solving approach, along with meticulous record-keeping in laboratory notebooks.
• Track record of scientific innovation showcased through publications, patents, and presentations at scientific conferences.
• Exceptional written and verbal communication skills, with the ability to convey complex scientific data effectively to cross-functional teams and senior management.

Desirable Skills/Experience:

• Experience with radioconjugates or radiolabeling is a plus.
• Experience in protein engineering and production would be advantageous.
• Familiarity with coordinating activities with Contract Research Organizations (CROs)
• Experience in non-oncology ADCs and oligo conjugation is a plus.

At AstraZeneca, we are on a mission to eliminate cancer as a cause of death. We are a science-based, leading and decisive Oncology enterprise united in our vision. We push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. We lead through true collaboration, building collective wisdom by giving everyone a chance to input. It's science with an impact-making a difference for patients and people around the world. Our pipeline is a testament to our growth, both now and in the future. Our values are evidence of our commitment to Oncology and our people.

About Our Gaithersburg Oncology Hub

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center, game rooms, community garden and more. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

So, what’s next?

Are you ready to join a team that is ambitious, collaborative, and optimistic in our ability to be resilient and work together towards a cure? Apply now and let's make a meaningful difference together!

If you’re curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Closing Date: September 10, 2024

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more-

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.