Associate Principal Scientist, Early Respiratory and Immunology

Are you passionate about science and eager to apply your expertise in a company that follows the science and turns ideas into life-changing medicines? If so, AstraZeneca might be the one for you! We are seeking an experienced and highly motivated researcher with a strong understanding of adaptive and/or highly developed immunity. This role will be based in Waltham, MA (Boston BioHub) within AstraZeneca’s innovative laboratories where you will follow the science to help drive innovation and advance medicines. This position offers a unique opportunity to work in a dynamic and innovative environment developing your career at the interface of mechanistic research, drug discovery, and preclinical drug development.

Accountabilities:

In this role, you will be a scientific leader in the Bioscience, Immunology team focusing on developing therapeutics for treatment of Rheumatological and Gastrointestinal Diseases. You will lead programs from target identification through preclinical development and will be responsible for the delivery of preclinical and translational data in support of key portfolio program milestones. You will take an active role in growing and developing team members and recruitment of new talents.

Essential Skills/Experience:

• Ph.D. in immunology or a relevant research area, with 5 years of industry experience in a relevant field, preferentially in drug discovery and development for autoimmune disease and/or inflammatory disease.
• Demonstrated leadership in driving drug discovery projects in immunology through preclinical milestones.
• Self-motivated and highly organized with the ability to work independently as well as collaboratively within a team to perform high-quality research.
• Solid understanding of T cell and/or Treg biology and hands-on experience are required; experience with cell therapy and other immune cell types is strongly preferred.
• Expertise in primary human cell culture, multi-color flow cytometry, multiplex cytokine detection, functional immune cell assays (proliferation, cytotoxicity, chemotaxis) and assay development is essential.
• Experience working with primary human tissue samples, and in vivo models of autoimmunity and inflammation is preferred.
• Strong hands-on skills in molecular biology are a plus.
• Experience with multiple drug modalities, including large molecule, small molecule or cell therapies is a plus.
• Experience in managing Ph.D. and/or non-Ph.D. level scientists is a plus.
• Demonstrated ability to identify and leverage internal and external resources to advance drug discovery efforts.
• Ability to work in a dynamic environment, record protocols and experiments detailed and in a timely manner and maintain an excellent laboratory notebook.
• Strong written and oral communication skills and the ability to critically analyze datasets are essential.

Desirable Skills/Experience:

• Experience with cell therapy
• Experience with multiple drug modalities
• Experience managing scientists

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca

At AstraZeneca, we are a science-based, leading and decisive Oncology enterprise united in our vision to eliminate cancer as a cause of death. We are on a mission to make big paradigm shifts in treatment options, identifying and treating patients earlier, early-stage cancer trials and listening to evolve with patients' needs. Our commitment to patients and pioneering spirit are truly embedded and it's what makes our pipeline unique. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. We lead through true collaboration, building collective wisdom by giving everyone a chance to input. It's science with an impact-making a difference for patients and people around the world.

Ready to make a difference? Apply today!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.