About the Compnay:

Addition Therapeutics is at the forefront of biotechnology innovation, advancing transformative therapies utilizing its proprietary PRINT™ (Precise RNA-mediated Insertion of Transgenes) platform. PRINT™ redefines genetic medicine by enabling development of RNA-only therapeutics capable of inserting any genetic element into specific safe harbor sites within the genome. Operating from state-of-the-art labs in South San Francisco, our team of experienced scientists and drug developers is leading scientific breakthroughs while cultivating a vibrant, dynamic culture committed to profoundly impacting patient lives.

Position Overview:

We are seeking a highly skilled and experienced Associate Director/Director of Protein Engineering to lead our research and development efforts in protein design, optimization, and engineering. The ideal candidate will have a strong background in protein engineering, molecular biology, and biochemistry, with demonstrated expertise in designing and engineering proteins for therapeutic applications. As the Associate Director/Director of Protein Engineering, you will play a critical role in driving innovation, leading a team of scientists and research associates, and contributing to the advancement of our pipeline of protein-based therapeutics and diagnostics.

Key Responsibilities:

• Lead and manage a team of scientists and research associates specializing in protein engineering, providing mentorship, guidance, and support to achieve project goals and objectives.
• Evaluate and implement protein engineering strategies to optimize retrotransposase expression, stability, and multiple functions in support of various therapeutic applications.
• Collaborate cross-functionally with other research and development teams to integrate protein engineering efforts into overall project plans and timelines.
• Contribute to intellectual property generation through the design and execution of innovative protein engineering experiments and studies.
• Present research findings, project updates, and scientific insights to internal stakeholders, external collaborators, and scientific conferences.

Qualifications:

• Ph.D. in Biochemistry, Molecular Biology, Protein Engineering, or related field.
• Minimum of ten years of post-graduate experience in protein engineering, with a proven track record of success in designing and engineering proteins for therapeutic applications.
• Strong expertise in protein structure-function relationships and characterization techniques.
• Experience managing and leading scientific teams, with demonstrated leadership, communication, and interpersonal skills.
• Proficiency in protein design software, molecular modeling tools, and protein expression systems.
• A history of engineering polymerases, endonucleases, and/or zinc-finger (or other) DNA-binding proteins
• Track record of publication in peer-reviewed journals and/or intellectual property generation in the field of protein engineering.
• Ability to thrive in a fast-paced, collaborative, and dynamic work environment.

Compensation

The expected annual salary range for this full-time position is $180,000 - $235,000, plus eligibility for bonus, benefits, and equity incentives. Actual pay will be determined based on experience, qualifications, business needs, internal equity, and alignment with market data.