The Principal Associate Scientist will be responsible for initial characterization testing, annual re-qualification, and trending of early-phase siRNA reference materials under the direction of the supervisor/manager. You will provide inter-departmental support by ensuring continuous supply and life cycle management of reference materials throughout the organization, at contract research organizations, and contract manufacturers.

Summary of Key Responsibilities:

• Perform in-house characterization [including E260 analysis], qualification, and re-qualification testing of early phase reference materials and document appropriately in notebook or electronic notebooks.
• Receive and handle requests from external contract labs/CMOs and internally to minimize or avoid any disruption to testing and supply.
• Perform and keep accurate inventory of reference materials up to date.
• Generate review reference material Certificates of Testing, characterization protocols, and reports. Extend re-test dates for reference materials, where applicable.
• Contribute data to characterization and structure elucidation sections of regulatory submissions and respond to agency requests on these sections, where applicable.
• Performs testing or data analysis of siRNA utilizing the following analytical techniques: pH, Osmolality, and UV Assay Assist with troubleshooting on a needed basis.
• Coordinate shipping of materials.

Educational Qualification:

Bachelor's degree in a science field, preferably chemistry or biochemistry