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Bio Analytical Scientist
Aequor Seattle, WA
$122k-151k (estimate)
Full Time | Ancillary Healthcare 7 Days Ago
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Aequor is Hiring a Bio Analytical Scientist Near Seattle, WA

Job Title: Bio Analytical Scientist
Location: Seattle, WA*Onsite
Top Skills:
  • Proven experience with physicochemical analytical techniques such as chromatography, electrophoresis/CE, etc. experience working with Waters UPLC system and Empower software
  • Methods: SEC-U/HPLC, SEC-MALS, IEX, RP-LC, Affinity, CE: PA800 (SCIEX) CE-SDS, CZE, cIEF
  • Experience with proteins characterization preferred
Position Summary:Cell Therapy Product and Analytical Development (P&AD) is seeking an enthusiastic, self-driven Scientist to join its Residual, Ancillary Materials and Protein Characterization analytical development team. The Scientist will lead development of analytical methods to characterize process-related impurities and assess impurity clearance in autologous and allogenic cell therapies. The Scientist will be responsible for developing impactful methods, including QC methods for lot release testing as well as characterization methods that support process development and comparability assessments. These methods will be used to further our understanding of cell therapies, and support development of manufacturing processes, and/or QC release of the drug product. The successful candidate must have extensive hands-on experience in assay development and possess excellent communication skills in order to work on projects requiring close collaboration with other groups, such as discovery research, product sciences, process development, and QC. Additionally, the Scientist will interface with external vendors (e.g., CMO's) for the successful management of any transferred analytical methods. The Scientist should be passionate about developing Client medicines, thrive in an intellectually challenging environment, and enjoy collaborating with a team of likeminded Scientists.
  • Roles and Responsibilities**
  • Serve as a subject matter expert responsible for developing robust analytical methods and expanding product and process understanding.
  • Independently develop and execute bioanalytical or molecular assays (e.g. chromatography, electrophoresis/CE assays)
  • Identify issues, lead troubleshooting experiments, and determine solutions with minimal to no guidance
  • Train users on method execution, data analyses, and proper use of instrumentation
  • Lead qualification and transfer of analytical methods to external stakeholders
  • Routinely present work at team, technical team, and department meetings
  • Maintain meticulous laboratory notebooks
  • Analyzing, interpreting, and presenting data to internal and external stakeholders (Power Point Presentations)
  • Author, review and approve technical documents, including methods, protocols, reports, and SOPs
  • Deliver lifecycle-managed analytical methods for multiple programs with an understanding of ICH/FDA/EMEA best practices and current thinking.
  • Facilitate smooth operation of the laboratory, including ordering, assisting in the cryopreservation of cellular material, sample management, etc.
**Qualifications & Experience**
Education:
  • BS, MS or PhD in Molecular Biology, Analytical Biochemistry, Immunology, Microbiology, Cell Biology, or related field. PhD with 0-3 years, or MS with 3 years, or BS with 7 years of relevant industry experience.
Basic Qualifications
  • Proven experience with physicochemical analytical techniques such as chromatography, electrophoresis/CE, etc.
  • experience working with Waters UPLC system and Empower software
  • Methods: SEC-U/HPLC, SEC-MALS, IEX, RP-LC, Affinity, CE: PA800 (SCIEX) CE-SDS, CZE, cIEF
  • Experience with proteins characterization preferred
  • Strong problem-solving ability to troubleshoot complex technical and scientific problems.
  • Experience with writing technical and regulatory documents for interdepartmental use and external vendors (e.g., CMO's).
  • Strong attention to detail.
  • Outstanding written and oral communication skills.
  • Work effectively in a collaborative team setting.
  • Ability to work in a rapidly changing environment with frequent changes in priorities.
Preferred Qualifications-
  • Knowledge of immunology and T cell biology as applied to the cell therapy field
  • Knowledge or experience with vector and gene editing analytics (AAV, CRISPR, etc)
  • Experience with molecular techniques (e.g., qPCR, RT-qPCR, and/or ddPCR).
  • Experience with data analysis and interpretation using software (e.g., Softmax Pro, Gen5, Excel, Prism Graphpad).
  • Familiarity with statistical analysis and design on experiments (DoE) using JMP software.
  • Track record of successful transfer and management of analytical methods
  • has context menu

Job Summary

JOB TYPE

Full Time

INDUSTRY

Ancillary Healthcare

SALARY

$122k-151k (estimate)

POST DATE

06/19/2024

EXPIRATION DATE

12/14/2024

WEBSITE

aequorinc.com

HEADQUARTERS

SAN DIEGO, CA

SIZE

<25

FOUNDED

2006

TYPE

Private

CEO

DANA BUCKMAN

REVENUE

<$5M

INDUSTRY

Ancillary Healthcare

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