Scientist I – Research Operations, Allen Institute for Neural Dynamics

The mission of the Allen Institute is to unlock the complexities of bioscience and advance our knowledge to improve human health. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.

The Allen Institute for Neural Dynamics is focused on making fundamental discoveries in systems neuroscience. We are interested in how the brain builds our understanding of the complex world to guide the flexible behaviors. The answers will be in terms of defined neuron types and circuits. Employing a team-based approach for discovery neuroscience, we strive to uncover the neural basis of behavior through technological innovation, cutting-edge experiments, modeling, and theory.

This Scientist will play a leading role in developing, implementing, and advancing methods to link neural activity measured in vivo using cutting-edge imaging to molecular characterization of these same neurons ex vivo. A key goal is to implement a robust multiplexed fluorescence in situ hybridization (mFISH) platform for thick neural tissue. This position requires a strong background in histology, in situ hybridization, microscopy, and molecular neuroscience. Because this platform will support multiple evolving projects, the ideal candidate will have excellent communication skills, an ability to adapt to changing requirements, and a desire to work collaboratively in a fast-paced, cross-functional team.

The Allen Institute believes that team science significantly benefits from the participation of diverse voices, experiences and backgrounds. High-quality science can only be produced when it includes different perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.

Essential Functions

• Apply cutting-edge lightsheet and confocal microscopy for neuroanatomical imaging
• Design, troubleshoot, and optimize mFISH protocols in thick tissue to improve data quality and increase throughput
• Help to define project goals aimed at understanding neuronal cell types, independently propose experimental strategies to achieve those goals, and execute in collaboration with other contributors
• Design innovative, complex multi-modal experiments and pipelines, and contribute to microscopy data analysis workflows
• Interact with and analyze large-scale imaging datasets, and develop Quality Assurance /Quality Control (QA/QC) procedures to ensure high quality data collection
• Train, mentor and motivate research technicians to perform complex experiments at scale

Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects management’s assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.

Required Education and Experience

• Ph.D. or equivalent in biological sciences, engineering, or related fields; or equivalent combination of degree and experience
• Experience with microscopy applications for biomedical sciences
• Demonstrated experience with fluorescence in situ hybridization techniques (e.g., MERFISH, HCR, etc.)
• Experience with image analysis software and related tools

Preferred Education and Experience

• 3 years postdoc relevant work or research experience
• Domain-specific knowledge in neuroscience/neuroanatomy
• Experience in designing, deploying and using high-throughput systems and pipelines for acquiring and processing spatial transcriptomic datasets
• Experience in managing complex projects from concept to completion
• Demonstrated ability to manage and mentor junior scientists
• Excellent project management skills
• Strong written and verbal communication skills

Work Environment

• May enter laboratory environment, including potential exposure to lasers and biohazards

Physical Demands

• Occasional lifting to 30 pounds
• Fine motor movements in fingers/hands to operate computers and lab equipment

Position Type/Expected Hours of Work

• Occasional evening and weekend hours required
• This role is currently working onsite and is expected to work onsite for the majority of working hours. The primary work location for this role is 615 Westlake Ave N., with the flexibility to work remotely on a limited basis.

Travel

• Attendance and participation in national and international conferences

Additional Comments

• **Please note, this opportunity offers work visa sponsorship **
• **Please note, this opportunity offersrelocation assistance**

Annualized Salary Range

$77,250 - $103,000*

* Final salary depends on the required education for the role, experience, level of skills relevant to the role, and work location, where applicable.

Benefits

Employees (and their families) are eligible to enroll in benefits per eligibility rules outlined in the Allen Institute’s Benefits Guide. These benefits include medical, dental, vision, and basic life insurance. Employees are also eligible to enroll in the Allen Institute’s 401k plan. Paid time off is also available as outlined in the Allen Institutes Benefits Guide. Details on the Allen Institute’s benefits offering are located at the following link to the Benefits Guide: https://alleninstitute.org/careers/benefits.

It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of ae, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities