Job description:

Job Title: Associate Scientist

Location: Seattle, WA

Duration: 12 months

Rate: $$$51.42 -$65.31/hr

Job Description:

Role: Associate Research Scientist

Location: Seattle, WA* 100% Onsite

The Assoc. Scientist will join the Gene Delivery and Editing Process Development (GDEPD) organization supporting process development for production of lipid nanoparticles (LNPs), which are critical to generating groundbreaking cell therapies.

The associate will join the LNP Platform Development team working on initiatives intended to drive next-generation LNP platform development focused on gene editing capabilities. Specifically, in the pursuit of end-to-end assessment of novel technologies and approaches, the associate will seek to become highly proficient in developing processes to produce and purify LNPs, while also gaining familiarity with analytical assays for characterization of LNPs. The associate will also have the unique opportunity to be exposed to a wide range of other gene editing technologies and will be encouraged to work collaboratively with a range of different groups doing different types of process development.

Responsibilities:

• Execute and troubleshoot process development experiments supporting LNP production and purification.

• Assist in the design of experiments and interpretation of data relating to LNP production and purification.

• Manage the flow of samples and data and perform analyses.

• Optimize workflows for assessing new modes of production and purification.

• Support research-to-development transition endeavors, including early-stage/pipeline molecular assessment activities.

• Actively participate and support lab maintenance and continuous improvement initiatives.

• Maintain accurate and detailed laboratory notebook and documentation.

• Summarize and present data in group meetings and contribute to group discussions and team strategy.

• Author technical reports and study memos.

Basic Qualifications:

• STEM degree with 2 years of relevant industry experience; title/compensation will ultimately be commensurate with education, experience, and skillset

• Demonstrated and extensive experience with TFF and sterile filtration of biological molecules

• Experience with JMP for DoE design and analyses

• Independently motivated with ability to work in teams

• Ability to communicate clearly and concisely through oral presentation and technical writing.

• Ability to leverage literature, internal and external resources to solve problems

• Desire to identify and advance the cutting edge

• Possess a growth mindset and the ability to thrive in a fast-paced, highly collaborative environment

Preferred Qualifications:

• Experience with production and purification of LNPs or molecule of similar nature.

• Degree in biological or chemical engineering, biochemistry, or bio-related field

• Experience with handling of nucleic acids

• Experience with LNP characterization techniques (HPLC, DLS, MALs, NTA, etc.)

• Experience downstream purification of biological molecules (AKTA, chromatography, TFF, viral filtration, etc.)

• Experience with development of continuous processes and implementation process-analytical technologies (PATs)

• Experience with microfluidic technologies

• Experience in the development of other gene delivery or editing materials (e.g. adeno-, retro-, lenti-, RNPs, Cas, mRNA, etc.)