Strive to Bring a Profound Difference to our Patients

At Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people’s lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients.

Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs™). Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is broadening the reach of AOCs with its advancing and expanding pipeline, including programs in cardiology and immunology through internal discovery efforts and key partnerships. Avidity is headquartered inSan Diego, CA.For more information about our AOC platform, clinical development pipeline, and people, please visitwww.aviditybiosciences.comand engage with us onLinkedInandTwitter.

The Opportunity

We are seeking a highly skilled and motivated Scientist to lead Bioanalytical Sciences organization at Avidity Biosciences in San Diego, CA. In the role, the group leader will oversee a group of PhD and associate level scientists responsible for the development, validation, and implementation of bioanalytical methods to support our drug discovery and development programs. The successful candidate will ensure high-quality data generation and interpretation, maintain compliance with regulatory standards, and drive continuous improvement within the team. Additional responsibilities include representing the Bioanalytical function on research and development teams, mentoring scientist team members, and communicating between functional areas, among others. We seek a candidate who enjoys scientific discovery, is team oriented and possess excellent communication skills that excels in a collaborative fast-paced interdisciplinary environment.

What You Will Contribute

• Lead, mentor, and manage the Bioanalytical Sciences team
• Define and implement program-specific bioanalytical strategies that spans preclinical drug discovery through late phase clinical development
• Expand and refine capabilities by integrating new methods and technologies
• Lead bioanalytical technical discussions for multiple programs
• Represent the PKPD Department on cross-functional project teams
• Manage relationships with external service providers
• Demonstrate effective presentational, verbal, and written communication

What We Seek

• PhD in Bioengineering, Biology, Biochemistry, or related discipline with at least 7 years of industry experience; alternatively, a highly qualified candidate with an MS degree and 10 years of relevant industry experience may be considered
• Direct experience leading teams and managing multiple scientists and technical staff with diverse skill sets
• Hands-on experience developing bioanalytical assays across multiple platforms including LC-MS/MS and ELISA/MSD
• Experience developing quantitative LC-MS assays for small molecules, peptides, proteins, oligonucleotides, oligonucleotide conjugates, and their metabolites from biological matrixes. Knowledge of Thermo Fisher Scientific instruments and software is preferred.
• Knowledge and experience with bioanalytical assays supporting protein or RNA therapeutics
• Knowledge of regulatory agency’s (FDA, EMA, etc..) requirement on method development, qualification and validation of bioanalytical assays
• Hands-on lab experience with various laboratory techniques including quantitative RT-PCR, cell culture, RNA isolation, RNA-seq, exosome purification is desired
• Experience working with external contract labs
• Experience with GxP bioanalytical assays is a plus
• Knowledge on various in-vitro & in-vivo bioanalytical assays to support ADME studies is a plus
• Excellent written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary

What We Will Provide to You:

• The base salary range for this role is $176,000 - $200,000. The final compensation will be commensurate with factors such as relevant experience, skill set, internal equity, and market factors.
• Avidity offers competitive compensation and benefits, including the opportunity for annual and spot bonuses, stock options, and RSUs, as well as a 401(k) with an employer match. In addition, the comprehensive wellness program includes coverage for medical, dental, vision, and LTD and four weeks of time off.
• A commitment to learning and development, which includes a variety of programming internally developed by and for Avidity employees, opportunities for job-specific training offered by industry, and an education reimbursement program.