Associate Scientist / Scientist, Lead Discovery

W2 Contract-to-Hire

Salary Range: $93,600 - $104,000 per year

Location: San Mateo County, CA - Onsite Role

Job Summary:

We are looking for an experienced scientist to help the Discovery Sciences team accelerate our search for new oncology therapeutics. You will become part of a top-tier team specializing in biochemical and biophysical screening techniques, focused on efficiently identifying and quickly developing clinically significant drugs targeting frontier areas in oncology. Working from the bench, you will assist in improving our methods for discovering inhibitors of both established and novel drug target proteins while also contributing to our mission of delivering high-quality experimental data for ongoing programs.

Duties and Responsibilities:

• Design and execute lead discovery screening methods and experiments to identify compound hits and advance them through hit-to-lead and lead optimization stages.
• Collaborate within Discovery Science and cross-functionally with Compound Management, Structural Biology, and Biology/Chemistry teams to develop and implement biochemical and biophysical assays for hit identification and lead optimization, evaluating compound potency, selectivity, and mechanism of action, biophysical and biochemical assay development.
• Develop, execute, and troubleshoot novel biochemical and biophysical assays to support screening and preclinical development.
• Communicate scientific progress effectively to the Discovery Sciences team and cross-functionally and facilitate project execution within established timelines.
• Generate, manage, evaluate, and maintain critical data in an organized manner and disseminate data broadly to relevant departments.
• Maintain detailed electronic lab notebook entries, draft experiment protocols and assay data summaries, and manage reagent stocks.

Requirements and Qualifications:

• PhD with 0-2 years experience or a Master's degree with 5 years of experience in biochemistry, biophysics, biotechnology, or a related field
• Hands-on protein biochemistry experience in biochemical/biophysical assay development, validation, and troubleshooting (e.g., characterizing and analyzing protein-ligand or protein-protein interactions)
• Proficient in the execution and analysis of in vitro biochemical and biophysical assays suitable for the discovery, validation, or mechanistic characterization of target molecules (ITC, SPR/BLI, TR-FRET, fluorescence polarization, etc.)
• Experience with data processing and visualization tools for data analysis and figure generation (e.g., R, Vortex, GraphPad Prism, Genedata Screener, etc).
• Attention to detail with excellent organizational, experimental data recording, and time management skills
• Excellent written and verbal communication skills
• Innovative and flexible team player with high energy and a demonstrated willingness to learn in a fast-paced environment

Preferred Skills:

• Familiarity with automated liquid handling, including SPT Dragonfly, Mosquito, Agilent Bravo, and Tecan
• Experience with high throughput screening
• Facile with instrumentation, able to troubleshoot problems and work with engineers to generate successful solutions to technical limitations.
• Rigorous, quantitative, detail-oriented experimentalist with an understanding of statistics

Bayside Solutions, Inc. may collect your personal information during the position application process. Please reference Bayside Solutions, Inc.'s CCPA Privacy Policy at www.baysidesolutions.com. Desired Skills and Experience Biochemistry, biophysics, biotechnology, assay development, in vitro, ITC, SPR/BLI, TR-FRET, fluorescence polarization, R, Vortex, GraphPad Prism, Genedata Screener, SPT Dragonfly, Mosquito, Agilent Bravo, Tecan, high throughput screening