Scientist I/II, Platform Biology

Department: Lab Science

Employment Type: Full Time

Location: San Mateo, CA

Description

Key Responsibilities

• Design, develop, and optimize cell-based functional assays utilizing a variety of techniques including flow cytometry, ELISA, and other molecular and cellular biology methods to assess antibody binding, kinetics, stability, and target engagement to support and scale up BigHat’s discovery efforts.
• Collaboratively design ambitious proof of concept experiments to guide strategy of novel target discovery campaigns.
• Lead efforts to onboard, expand, and optimize cell growth conditions, from transfection through productivity screening.
• Optimize and transfer cell-based functional assays to a high-throughput, production-grade format.
• Contribute to the advancement of our platform by exploration and implementation of innovative methodologies and technologies.
• Analyze experimental data, interpret results, and generate actionable insights to drive project decision-making.
• Collaborate cross-functionally between Programs, Data Science, and Machine Learning team members to ensure streamlined data capture, collection, and processing.
• Effectively and regularly synthesize and communicate results and research activity to key decision makers and the broader BigHat team.

Skills Knowledge and Expertise

• PhD in Immunology, Biology, Chemistry, or similar field, with 1 years of industry experience or equivalent.
• Demonstrated expertise in cell line establishment, maintenance and manipulation, preferably in the context of cancer immunotherapy.
• Proven track record of developing and optimizing complex cellular and molecular assays for immuno-oncology targets, including flow cytometry, ELISA, and functional assays.
• Proficiency in data analysis and interpretation, with experience using relevant software and statistical tools including readily learning new software tools.
• Excellent communication and presentation skills, with the ability to effectively communicate complex scientific concepts to diverse audiences.
• Experience with T cell engagers, antibody-drug conjugates, and/or multispecific antibodies.
• If you love asking questions, tinkering, and diving headfirst into diverse, highly technical projects BigHat could be the right home for you!