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The Target Discovery team is seeking an innovative and motivated Scientist, with deep experience in molecular biology, to contribute to the design and development of AAV vectors for the treatment of genetic and acquired forms of hearing loss. A successful candidate will work independently and cross-functionally with various teams to perform benchwork that supports discovery efforts and contribute to IND-enabling studies. The scope of work includes the design, execution, and analysis of in vitro and ex vivo experiments using novel AAV vectors. The successful candidate will be self-motivated and creative, with a desire to succeed at the highest level in a highly collaborative and fast-paced environment.
Job Responsibilities

• Execute in vitro and ex vivo nonclinical experiments for the development of genetic medicines for the inner ear, including cell culture transfection/transduction, cochlear explant generation and analysis, and various molecular readouts such as flow cytometry, ddPCR/qPCR, and western blot.
• Support in vivo studies with molecular analysis of cochlear tissue for DNA, RNA, and protein readouts.
• Maintain accurate and timely documentation of activities through meticulous lab notebook practices and contributions to reports.
• Analyze, interpret, and present data, with the ability to clearly communicate results in written and oral formats; may need to incorporate data from other members in the Research team to interpret data.
• Collaborate closely with cross-functional teams and external groups to coordinate and drive complex studies.

Basic Qualifications

• Ph.D. in cellular/molecular biology, virology, or neuroscience, or Master’s degree in relevant scientific discipline with 6 years of relevant industry experience; biotech or pharmaceutical industry experience preferred

Additional Skills

• Experience with RNA (qPCR and ddPCR) and protein analyses (western blot). Single-cell analysis pipeline experience preferred
• Experience with tissue micro-dissections; inner ear dissections preferred
• Demonstrated ability to function as a member of an interdisciplinary team and contribute within a highly collaborative environment
• Exceptionally creative, organized, and detail-oriented
• Excellent communication skills, with the ability to thoroughly document, interpret, and effectively present scientific data to other scientists and non-scientists.

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