OPPORTUNITY
We are currently seeking a highly motivated Senior Research Associate/Associate Scientist to join our Extrahepatic therapeutic genome editing team at Mammoth Biosciences. The successful candidate will conduct translational gene editing experiments and make significant contributions to multiple projects within Mammoth's CNS therapeutics pipeline. Specifically, the candidate will work closely with the hiring manager and Extrahepatic therapeutics team to design/develop, perform and execute studies on in vitro and in vivo models to support the development of proprietary Mammoth genome-editing systems for CNS disease therapeutic strategies. The position requires adaptability, excellent technical and analytical skills, strong organizational and communication skills, as well as the ability to work independently in a fast-paced team-oriented and dynamic environment.
KEY RESPONSIBILITIES

• Execution of molecular biology, cloning, cell culture, genome editing, transfection, viral transduction and a broad range of functional assays to support screening and optimization of Mammoth genome editing systems
• Perform analysis of genome editing and functional outcomes in cellular or animal models of CNS disease
• Accurately and timely record, document, analyze and communicate laboratory data to senior staff and team members
• Conduct all activities in a safe and efficient manner, and adheres to site environmental health and safety (EHS) requirements

REQUIRED QUALIFICATIONS

• Bachelor's degree in molecular and cell biology, immunology, biochemistry, or a related field
• Minimum 2 years (4 years for Associate Scientist) of relevant academic or industry laboratory research experience
• Knowledge of genome editing systems
• Proficiency in mammalian cell culture, transfections, molecular cloning, PCR, genomic DNA and mRNA purification, cDNA library prep, qPCR, ELISA, western blot

PREFERRED QUALIFICATIONS

• Bachelor's or master's degree in neuroscience, or a related field
• Prior industry work experience
• Proficiency in viral transductions, ddPCR, NGS sample prep / analysis, flow cytometry
• Experience working with genome editing systems
• Experience working with AAV or LNP delivery systems
• Experience with neuronal or patient-derived primary cell lines (SH-SY5Y, neural progenitor cells, neural stem cells, iPSC-derived neurons)
• Knowledge or experience working with automated liquid-handler systems
• Knowledge of Microsoft Office Suite and other relevant data analysis software (Flowjo, GraphPad Prism, etc.)
• Strong organizational and record-keeping skills, excellent interpersonal, verbal and written communication skills. Highly motivated with a strong work ethic. Ability to work efficiently and productively in a fast-paced highly collaborative team environment

BENEFITS

• Company-paid health/vision/dental benefits
• Unlimited vacation and generous sick time
• Company-sponsored meals and snacks
• Wellness, caregiver and ergonomics benefits
• 401(k) with company matching

Base Salary Range: $108,000 - $127,349
The listed base salary range is for Mammoth employees in the Bay Area. Actual base salary will be determined by geographic work location, relevant professional experience, applicable skills, and internal equity. The base salary range for those working remotely outside of the San Francisco Bay Area may differ and will be determined by industry market data for the role and specific region.
COMPANY
Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company's ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth's deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.
It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth, and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.
Mammoth Biosciences requires that all employees be vaccinated against COVID-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.