Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through the Lerner Research Institute. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years.A postdoctoral fellow position is available immediately in the laboratory of Dr. Laura Nagy in the Department of Inflammation and Immunity at the Cleveland Clinic to study the role of the innate immune system, including toll-like receptor signal transduction and complement activation, in the progression of alcohol-associated liver disease (ALD). The research will focus on the effects of chronic ethanol on key signal transduction pathways in circulating monocytes, hepatocytes and hepatic macrophages with a goal towards understanding the mechanism of development of chronic inflammatory responses and hepatocyte injury in liver.We are a part of the AlcHepNet consortium with access to samples from both observational and randomized clinical trials in patients with ALD, allowing research to have molecular, cellular, physiological and translational impact. Experience in at least one of the following areas is desired: complement, cell biology, signal transduction, molecular biology, bioinformatics or macrophage biology. Experience in experimental design and data analysis in cultured cells, animal models and human data is preferred. Strong written and oral communication skills are required.Candidates should have a recent PhD in cell biology, immunology, biochemistry, or a related discipline and experience in signal transduction and cell biology.Principal Investigator: Laura E. Nagy, PhDLerner Research Institute Department: Inflammation and ImmunityLab Research Topics:Liver DiseaseInnate ImmunityComplementCell DeathInflammationFor more information about the lab's research, please visit: or contact Dr. Nagy at Responsibilities:Independent project design with the goal of data generation, analysis, interpretation and manuscript preparationConduct original researchPublish original researchPresent research at conferencesWrite individual fellowships/grant proposalsEducation:PhD or MD/PhD requiredMD with relevant laboratory experience may substitute for PhDLanguages:English Proficiency proof required for candidates arriving on J-1, J-2, or F1 OPT visa statusWork Experience:Previous experience in a research or academic setting. Graduate student experience meets this requirement.Scientific writing experienceAdditional Preferred Qualities:Basic and translational research experienceBioinformatics expertiseCell and molecular biology experiencePhysical Requirements:Ability to perform work in a stationary position for extended periodsAbility to operate a computer and other office equipmentAbility to communicate and exchange accurate informationAbility to distinguish colorManual dexterity to handle specimens and repair equipmentAbility to lift and transport equipment or specimens weighing up to 20 poundsMay be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc.Personal Protective Equipment:PPE per institutional requirements; may vary by laboratoryPreferred Application Materials:All application materials should be submitted directly via email to Laura Nagy at : Postdoc, Research, LRI, Complement, Biomarker, Alcohol-associated liver disease, NASH, NAFLD, Cytokines, PAMPs, Gut-liver interaction, Microbiome, Necroptosis, Apoptosis, Hepatocytes, Aacrophage, Adipose tissue, Kidney injuryPay RangeMinimum hourly: $0.01Maximum hourly: $333,340.26The pay range displayed on this job posting reflects the anticipated range for new hires. While the pay range is displayed as an hourly rate, Cleveland Clinic recruiters will clarify whether the compensation is hourly or salary. A successful candidate's actual compensation will be determined after taking factors into consideration such as the candidate's work history, experience, skill set, and education. This is not inclusive of the value of Cleveland Clinic's benefits package, which includes among other benefits, healthcare/dental/vision and retirement.