At Corner Therapeutics, Inc., our mission is to transform standard of care, ushering in a new era of robust, rapid, patient-friendly and low-cost immunotherapies – even for the most difficult to treat diseases. Our versatile dendritic cell hyperactivation (hDC) platform is unique in its ability to address a virtually unbounded range of cancers and infectious diseases which induces exceptional memory T cell responses that provide robust and durable immunity. Our dynamic workplace has tremendous opportunity for growth, and we are seeking talented individuals who are inspired and motivated to make exponential strides in curing disease through immunotherapy treatments.

The Role

The Senior Research Associate will help drive multiple projects forward in a collaborative, fast-paced environment. The successful candidate will possess keen attention to detail, the ability to multitask, be a problem solver, and enjoy working independently. This role will have an opportunity to learn new skills and be involved in assay development and optimization for vaccine drug products destined for clinical programs. This role will encompass a broad array of scientific assays necessary for immuno-oncology and infectious disease drug development and drug delivery applications. Candidates for this role should be self-motivated and organized, familiar with the relevant literature, and enjoy scientific investigation and thinking. The role will require technical proficiency, scientific creativity and exercise independent thought in developing methods, techniques, and evaluation of results while working in a fast-paced collaborative team environment.

Responsibilities

• Contribute to bioassay method development: optimizing and establishing cell-based potency assays to determine the potency of drug substances and drug products.
• Cell-based assays to evaluate cellular response for viability and cytokine secretion, as well as MoA studies.
• Perform immunological assays such as multi-color flow cytometry, ELISA, functional assays, and cell-based reporter assays.
• Isolate and cryogenically store immune cell populations from human blood products using immuno-magnetic beads.
• Characterization and stability testing of drug product formulations.
• Responsible for procurement, production and maintenance of critical reagents, cell lines, and cell banks required for experiments.
• Characterize physiochemical properties of drug products (size, zeta-potential, morphology, concentration, stability, interaction with proteins, etc.) using different techniques.
• Develop assays to evaluate degradation pathways and define critical quality attributes of drug substances, drug delivery platforms and drug products.
• Assist in maintaining general lab safety and functionality, including maintenance of equipment.
• Ability to recognize anomalous and inconsistent results and interpret experimental outcomes.
• Organize details, analyze data, troubleshoot, and communicate findings in team meetings.
• Proactively identify issues and develop solutions in a collaborative multidisciplinary environment.
• Plan and coordinate scheduling for experiments with other group members.
• Clearly and accurately document experimental work in an electronic lab notebook.

Preferred Qualifications

• BS with 4 years or MS with 2 year laboratory research experience (industry preferred) in biology, immunology, biochemistry, or equivalent.
• Experience with aseptic technique and mammalian cell culture skills is critical. Previous experience with primary cell lines is a plus.
• Proficiency with immunological and biological assays (flow cytometry, ELISA, western blotting, etc.) and troubleshooting is a plus.
• Previous experience using Benchling as an electronic lab notebook platform is a plus.

The Culture

We at Corner Therapeutics seek to attract individuals who believe in delivering exponential hope and impact for patients living with devastating disease. Guided by a shared love of learning and aspirations for scientific excellence, we hold a common belief that work communities should be a place of diverse ideas, mindful focus and authentic fun. We take a shared ownership approach towards building an amazing people- and patient centric culture. Game-changing science and bold business scaling can only be achieved when passionate people commit collaboratively to an extraordinary vision and to each other. We hope you will join us!

Let’s build something bold, TOGETHER.

The Benefits

• Corner Therapeutics also seeks to build a robust total rewards and benefits package that supports the physical, mental and financial wellness of every team member with: 
• Medical, Dental, Vision and company-supplemented Health Savings Account (HSA)
• 4 weeks’ vacation (with roll-over available), 5 sick days and 12 paid holidays
• 401K with company match
• Long- and short-term disability, Life insurance.
• Amazing colleagues in a dynamic start-up environment 
• A new biotech building with FREE parking near Watertown’s vibrant Arsenal Yards!

Corner Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.