Overview

Dana-Farber Cancer Institute (DFCI) and Deerfield Management have created the Center for Protein Degradation (CPD) at DFCI. The CPD has created a next-generation protein degrader and molecular glue platform to advance novel therapeutic modalities. This is an exceptional opportunity to join a newly founded research center that is pushing the boundaries of targeted protein degradation research and accelerating the translation of basic science into clinical solutions. Join our highly interactive team of scientists where we are creating new avenues of therapeutic intervention.

Our Culture

CPD believes...

* learning is paramount, failure is necessary to succeed, and humility is an asset.

* every individual should have the opportunity to provide and solicit feedback; asking for help is a strength.

* in helping others succeed - we celebrate our successes together and recognize the contributions of the team.

* in scientific excellence, challenging dogma, and asking "WHY?"

* our research must push scientific boundaries and accelerate the discovery of transformational medicines.

The Center for Protein Degradation (CPD) is seeking a biologist/biochemist to join the Biochemistry and Structural Biology team. The individual will work as part of a multidisciplinary team to identify and characterize novel molecular glues and degraders.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Responsibilities

* Conduct standardized biological or biochemical assays and laboratory analyses, eg. TR-FRET, FP, western blot, cell-based assays

* Maintains cell culture and optimizes protein purifications using various expression systems such as coli, insect and mammalian systems

* Compiles and analyzes experimental data and interprets results to write summaries of findings for presentation of results to staff

* Uses computers, computer-interfaced equipment, robotics or high-technology applications to perform work duties

* Responsible for maintaining detailed notebook of all work-related activities.

Research Associate I - No supervisory responsibilities.

Specialized Responsibilities, by Scientific Area:

Biochemistry: Conduct standard biological or biochemical assays and laboratory analyses, e.g., TR-FRET, FP, AlphaScreen, ELISA, and cell-based assays, etc. Purify and prepare proteins for the in-vitro assays.

Biology: Conduct cellular, ex vivo, and/or in vivo experiments. Conduct standard biological and laboratory analyses and assays, e.g., pharmacodynamic, etc.

Qualifications

* Bachelor's Degree (required), with a major in biochemistry, biology or related field

* At least 1 year lab experience post-Bachelor's

* Knowledge of state-of-the-art information and techniques related to either biochemistry or cancer biology

* Experience with ELISA, qPCR and molecular biology techniques preferred.

* Must have excellent communication skills (written and verbal) and be able to keep accurate experimental records

* Ability to analyze information and use logic to address work-related issues and problems

* Must have close attention to detail and good time management

* Ability to work within a team environment

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply. Bachelor's degree required; major in biology or chemistry preferred. Typically has 0-1 year of previous professional experience. Learns and uses technical principles, processes, and concepts. Applies policies and procedures to resolve routine issues. Works on problems of limited scope and follows standard SOPs to analyze situations and data. Builds stable internal working relationships.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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