Overview

The Sethi Laboratory is looking to recruit an exceptional scientist to join their dedicated, diverse, and collaborative team. We seek a motivated, collegial, dedicated, and diligent Master’s or Ph.D. graduate with a strong background in genetic and xenograft mouse models as well as excellent managerial/leadership skills.

This position is responsible for (1) promoting innovative in vivo studies and (2) leading management of a basic and translational research program by overseeing laboratory operations, including organization of mice colonies. Responsibility will include (1) executing high-quality in vivo experiments and (2) assistance with PI’s administrative responsibilities in the laboratory and supervision of technical staff to maintain good laboratory practice. This individual will report directly to the PI and work closely with the laboratory team, lab administrator, and grants manager. Scientist (50%) – facilitate & innovate upon in vivo gastrointestinal cancer mouse models

Lab manager (50%) – lead training, organization, and operations of basic and translational research laboratory

The Sethi Laboratory is in the divisions of Molecular and Cellular Oncology and Gastrointestinal Oncology in the Medical Oncology Department at Dana-Farber Cancer Institute and Harvard Medical School. We are part of the Cancer Program at the Broad Institute, Harvard Digestive Disease Center, and Gastrointestinal Malignancies at Dana-Farber/Harvard Cancer Center. Our overall goal is to combine clinical observations and patient-derived data with rigorous basic science investigation to yield opportunities for impactful translational advances. Our passion for investigative research is fundamentally dependent upon its power to generate a deeper understanding of human disease and ultimately improve patient care. We are particularly committed to defining the fundamental mechanisms underlying gastrointestinal cancers with the hope that such insight will translate into new prevention and treatment methods (https://sethilab.dana-farber.org/). Our work has been published in journals such as Cancer Cell, Nature Genetics, Science Advances, Nature Communications, Clinical Cancer Research, and Gastroenterology.

Located in Boston, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Responsibilities

This position is responsible for (1) promoting innovative in vivo studies and (2) leading management of a basic and translational research program by overseeing laboratory operations, including organization of mice colonies. Responsibility will include (1) executing high-quality in vivo experiments and (2) assistance with PI’s administrative responsibilities in the laboratory and supervision of technical staff to maintain good laboratory practice. This individual will report directly to the PI and work closely with the laboratory team, lab administrator, and grants manager. Scientist (50%) – facilitate & innovate upon in vivo gastrointestinal cancer mouse models

Lab manager (50%) – lead training, organization, and operations of basic and translational research laboratory.

SCIENTIST

• Collaboratively design, manage, and perform in vivo research
• Proficient in maintaining mouse colonies and executing in vivo experiments
• Directly train and supervise junior technical assistants and students
• Actively mentor junior team members with a desire to teach
• Analyze experimental data and interpret results; write reports and summaries of findings
• Prepare scientific presentations and publications
• Interact with collaborators

MANAGER

• Manage short- and long-term goals and costs of mouse research
• Conduct standardized biological, microbiological or biochemical laboratory tests (e.g., mycoplasma)
• Lead for generating common laboratory reagents (e.g., competent cells, organize condition media collection)
• Responsible for inventory and ordering of common supplies required for lab operations.
• Helps organize storage space for lab members and rotating lab meeting schedule
• Standardizes lab protocols

Qualifications

Master’s or Ph.D. training will be considered. Significant experience in genetic mouse models and standard laboratory techniques is required. The candidate should be organized with strong leadership skills. Please send a CV, letter of interest and list of three references to nilay_sethi@dfci.harvard.edu to apply. Position can start as soon as summer 2024

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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